鼠神经生长因子对急性期特发性面神经麻痹患者面神经传导功能的影响  

Effect of rat nerve growth factor on facial nerve conduction function in patients with acute idiopathic facial paralysis

作　　者：郭元明 马建法 孙晓 陈聪聪 刘崇[3] GUO Yuan-ming;MA Jian-fa;SUN Xiao;CHEN Cong-cong;LIU Chong

机构地区：[1]河南省直第三人民医院神经内科,473000 [2]河南省直第三人民医院康复医学科,473000 [3]南阳市第一人民医院神经内科,473000

出　　处：《中国疗养医学》2023年第5期536-539,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的基于面神经电图参数探究对急性期特发性面神经麻痹患者应用鼠神经生长因子治疗后,患者面神经传导功能及内皮功能的变化及临床意义。方法选取河南省直第三人民医院神经内科2020年7月至2022年4月期89例急性期特发性面神经麻痹患者作为研究对象,根据随机数字表将其分为对照组和观察组。对照组44例给予地塞米松、更昔洛韦、甲钴胺针等常规治疗,观察组45例联合注射用鼠神经生长因子治疗,对比两组患者面神经功能、神经传导功能、内皮功能及不良反应发生情况。结果治疗后观察组Sunny brook评分为(90.34±2.24)分,面瘫评分标准(Portmann)为(13.83±2.34)分、面部残疾指数(FDIP)评分为(20.54±2.28)分高于对照组Sunny brook评分(81.27±2.18)分,面Portmann(12.18±2.12)分、FDIP评分(19.06±2.04)分,面部残疾社会生活指数(FDIS)为(10.08±2.05)低于对照组FDIS(11.66±2.24)分(P<0.05);治疗后观察组额肌M波波幅(0.79±0.16)mV、眼轮匝肌M波波幅(1.25±0.38)mV、口轮匝肌M波波幅(1.79±0.41)mV、上唇方肌M波波幅(2.09±0.43)mV均高于对照组额肌M波波幅(0.35±0.04)mV、眼轮匝肌M波波幅(1.09±0.22)mV、口轮匝肌M波波幅(1.29±0.20)mV、上唇方肌M波波幅(1.79±0.38)mV,运动潜伏期均小于对照组(P<0.05);治疗后,观察组患者内皮素(ET)水平(87.12±3.75)pg/mL低于对照组ET水平(121.45±3.32)pg/mL,一氧化氮(NO)水平(65.06±3.54)μmol/mL高于对照组NO水平(43.26±3.64)μmol/mL(P<0.05);治疗期间两组患者不良反应总发生率对比差异无统计学意义(P>0.05)。结论在常规治疗的基础上联合鼠神经因子对急性期面神经麻痹患者进行治疗,可以提高患者预后面神经功能,改善神经传导功能和内皮功能,还具有一定的药物安全性。Objective To explore the changes and clinical significance of facial nerve conduction function and endothelial function in patients with acute idiopathic facial paralysis after treatment with rat nerve growth factor based on facial nerve electrogram parameters.Methods 89 patients with acute idiopathic facial paralysis in the Department of Neurology of the Third People's Hospital of Henan Province from July 2020 to April 2022 were selected as the study subjects.They were divided into control group and observation group according to the random number table.44 patients in the control group were treated with Dexamethasone,Ganciclovir,Mecobalamin injection and other conventional treatments,while 45 patients in the observation group were treated with injection of rat nerve growth factor.The facial nerve function,nerve conduction function,endothelial function and adverse reactions were compared between the two groups.Results After treatment in the observation group,the Sunnybrook score was(90.34±2.24)points,the facial paralysis score standard(Portmann)was(13.83±2.34)points,and the facial disability index(FDIP)score was(20.54±2.28)points,which were higher than the Sunnybrook score of(81.27±2.18)points,the facial Portmann score of(12.18±2.12)points,the FDIP score of(19.06±2.04)points in the control group.The facial disability index social(FDIS)(10.08±2.05)points was lower than the FDIS score of the control group(11.66±2.24)points(P<0.05);After treatment,the M wave amplitude of frontal muscle(0.79±0.16)mV,orbicularis oculi muscle(1.25±0.38)mV,orbicularis oris muscle(1.79±0.41)mV,and quadratus labii muscle(2.09±0.43)mV in the observation group were higher than those in the control group of the M wave amplitude of frontal muscle(0.35±0.04)mV,orbicularis oculi muscle(1.09±0.22)mV,orbicularis oris muscle(1.29±0.20)mV,and quadratus labii muscle(1.79±0.38)mV.The latency of exercise were lower than that of the control group(P<0.05);After treatment,the level of endothelin(ET)in the observation group(87.12±3.75)pg/

关 键 词：面神经电图参数 鼠神经生长因子 急性期特发性面神经麻痹 面神经传导功能 

分 类 号：R745.12[医药卫生—神经病学与精神病学]