G6PD测定在新生儿黄疸中的运用及意义分析  

Application and Significance Analysis of G6PD in Neonatal Jaundice

作　　者：吴雯雯 杨晓冬[2] 龚启斌[2] WU Wenwen;YANG Xiaodong;GONG Qibin(Neonatal Disease Screening Laboratory,Ningde Maternal and Child Health Hospital,Fujian Province,Ningde Fujian 352100,China;Department of Clinical Laboratory,Ningde City Hospital,Ningde Teachers'Affiliated College,Ningde Fujian 352100,China)

机构地区：[1]福建省宁德市妇幼保健院新生儿疾病筛查实验室,福建宁德352100 [2]宁德师范附属学院宁德市医院检验科,福建宁德352100

出　　处：《中国卫生标准管理》2023年第6期22-25,共4页China Health Standard Management

摘　　要：目的新生儿黄疸疾病检测期间,以红细胞葡萄糖-6-磷酸脱氢酶(erythrocyte glucose-6-phosphate dehydrogenase,G6PD)测定,分析新生儿黄疸中的运用及意义,并有效分析病理性黄疸与新生儿的相关性,及早期干预价值探究。方法选取2019年11月—2020年11月福建省宁德市妇幼保健院收治的4000例新生儿,均参与G6PD筛查,并将其研究结果进行分组,以G6PD缺乏组、正常组进行区分,并详细记录两组新生儿黄疸指标。结果(1)新生儿G6PD缺乏症筛查情况。福建省宁德市妇幼保健院新生儿G6PD缺乏症筛查发生率为1.45%(58/4000),其中男2.09%(46/2200),女0.56%(12/1800),G6PD正常新生儿有3942例。(2)新生儿病理性黄疸疾病与G6PD缺失存在正相关性。据研究,正常组新生儿病理性黄疸发生率为7.66%(302/3942),G6PD缺乏组新生儿病理性黄疸发生率为34.48%(20/58),组间差异有统计学意义(P<0.05)。结论新生儿出生后病理性黄疸症状主要因素为G6PD缺乏,临床通过该项指标的测定,能够有效掌握患儿体内病症情况,并以此作为诊断标准,对后续疾病的掌握、治疗等工作具有重要意义,值得临床广泛使用。Objective To analyze the application and significance of neonatal jaundice by G6PD during the detection of neonatal jaundice,and to effectively analyze the correlation between pathological jaundice and newborn,and explore the value of early intervention.Methods From November 2019 to November 2020,a total of 4000 newborns admitted to Ningde Maternal and Child Health Hospital in Fujian Province were selected.All the children included in the study participated in G6PD screening,and the research results were grouped,and the G6PD deficiency group and the normal group were distinguished,and the neonatal jaundice indicators of the two groups were recorded in detail.Results(1)Newborn G6PD deficiency screening.The incidence of neonatal G6PD deficiency screening in Ningde Maternal and Child Health Hospital of Fujian Province was 1.45%(58/4000),including 2.09%males(46/2200)and 0.56%females(12/1800).There were 3942 newborns with normal G6PD.(2)There was a positive correlation between neonatal pathological jaundice and G6PD deficiency.According to the research,the incidence of neonatal pathologic jaundice in the normal group was 7.66%(302/3942),and that in the G6PD deficiency group was 34.48%(20/58).There was significant difference between the two groups(P<0.05).Conclusion The main factor of neonatal pathological jaundice symptoms after birth is G6PD deficiency.Through the determination of this index,we can effectively grasp the internal conditions of children,and use it as a diagnostic standard,which is of great significance to the mastery and treatment of subsequent diseases,and is worthy of wide clinical use.

关 键 词：红细胞葡萄糖-6-磷酸脱氢酶 G6PD测定 新生儿 黄疸 G6PD缺乏症 诊断 运用意义 

分 类 号：R722[医药卫生—儿科]