60例乳腺叶状肿瘤的临床病理特征分析  

Clinicopathological Features of 60 Cases of Phyllodes Breast Neoplasms

作　　者：林维方 郭荣年 LIN Weifang;GUO Rongnian(Department of Pathology,Longyan First Hospital Affiliated to Fujian Medical University,Longyan Fujian 364011,China)

机构地区：[1]福建医科大学附属龙岩第一医院病理科,福建龙岩364011

出　　处：《中国卫生标准管理》2023年第6期96-99,共4页China Health Standard Management

摘　　要：目的研究60例乳腺叶状肿瘤患者的病理特征,并对其进行分析。方法采用回顾式分析的方法,分析2018年1月—2022年5月到福建医科大学附属龙岩第一医院就诊的60例乳腺叶状肿瘤(phyllodes tumor,PT)患者。将其分为良性肿瘤组(29例)和非良性肿瘤组(31例),对两组患者的临床特征(发病年龄、病程年限、肿瘤的直径以及血流阻力指数)和病理特征(肿瘤生长方式、核分裂情况、核异型性、间质细胞生长情况和肿瘤坏死情况)进行分析,以Logistic回归分析判断其病理学特征与预后的关系。结果对于良性、非良性肿瘤的病理学特征比较,良性肿瘤的膨胀式生长、核分裂数<5个、轻度核异型性、没有发生间质生长的情况、没有发生肿瘤坏死的情况的人数均多于非良性肿瘤,差异有统计学意义(P<0.05)。非良性肿瘤的浸润式生长、核分裂数≥5个、中重度核异型性、发生间质生长情况与发生肿瘤生长情况的人数均多于良性肿瘤,差异有统计学意义(P<0.05)。对于良性、非良性叶状肿瘤的临床特征比较,良性肿瘤患者的年龄、病程年限、肿瘤直径、血流阻力指数均小于肺恶性肿瘤患者,差异有统计学意义(P<0.05)。对于良性、非良性肿瘤边缘状况、囊变、血流等级比较,良性肿瘤发生囊变、内部回声均匀、血液等级1、2级的患者人数均多于非良性肿瘤患者,肿瘤边缘分叶情况于血流等级3、4级的人数均少于非良性肿瘤患者,差异统计学意义(P<0.05)。对于乳腺PT患者的预后影响因素比较,肿瘤生长形式、核分裂、核异型性、间质生长、肿瘤坏死均为影响乳腺PT患者预后的影响因素。结论良性肿瘤与非良性肿瘤之间的病理特征存在明显差异,可将乳腺PT的病理分析作为其诊断方法以及判断预后的指标。Objective To study and analyze the pathological features of 60 patients with phyllodes tumor of the breast.Methods By retrospective analysis,a total of 60 patients with breast phyllodes tumors(PT)presenting to Longyan First Hospital Affiliated to Fujian Medical University from January 2018 to May 2022 were analyzed.It was divided into benign tumor group(29 cases)and non-benign tumor group(31 cases),the clinical characteristics of patients in two groups(age of onset,duration of disease,tumor diameter,and flow resistance index)and pathological characteristics(tumor growth mode,nuclear division,nuclear atypia,stromal cell growth and tumor necrosis)were analyzed,logistic regression analysis to determine the relationship between the pathological characteristics and prognosis.Results For the comparison of the pathological features of benign and non-benign tumors,the number of benign tumors with expansive growth,mitoses<5,mild nuclear atypia,no stromal growth,and no tumor necrosis were more than non-benign tumors,with statistical difference(P<0.05);non-benign tumors have more infiltrative growth,mitotic number≥5,moderate to severe nuclear atypia,stromal growth and tumor growth than benign tumors,with a statistical difference(P<0.05).For the comparison of the clinical characteristics of benign and non-benign phyllodes tumors,the age,duration of disease,tumor diameter,and blood flow resistance index of benign tumor patients were all lower than those of lung cancer patients,with statistical differences(P<0.05).For the comparison of benign and non-benign tumor margins,cystic degeneration,and blood flow grades,benign tumors with cystic degeneration,uniform internal echo,and blood grades 1 and 2 were more than those with non-benign tumors.The number of blood flow grades 3 and 4 was less than that of patients with non-benign tumors,and there was a statistical difference(P<0.05).For the comparison of prognostic factors in breast PT patients,tumor growth pattern,mitoses,nuclear atypia,interstitial growth,tumor necrosis were al

关 键 词：乳腺肿瘤 叶状瘤 病理特征 影响因素 病理分析 诊断方法 

分 类 号：R737[医药卫生—肿瘤]