有效白蛋白浓度在慢性肝病治疗中应用的认识  

Application of effective albumin concentration in treatment of chronic liver disease

作　　者：王银玲 刘昱含 朱传武[1] Yin-Ling Wang;Yu-Han Liu;Chuan-Wu Zhu(partment of Liver Diseases,The Fifth People’s Hospital of Suzhou,Suzhou 215000,Jiangsu Province,China;Takeda(China)Pharmaceutical Company Limited,Shanghai 200124,China)

机构地区：[1]苏州市第五人民医院肝病科,江苏省苏州市215000 [2]武田(中国)投资有限公司,上海市200124

出　　处：《世界华人消化杂志》2023年第6期214-220,共7页World Chinese Journal of Digestology

基　　金：江苏省科技厅基金项目,No.BK20211080;苏州市科学技术局基金项目,No.SKY2021059;苏州市姑苏卫生人才计划项目,No.GSWS2020091.

摘　　要：白蛋白是一种非糖基化血浆蛋白,除了增加血容量和维持血浆胶体渗透压外,还具有转运、抗氧化、抗炎、免疫调节等多种生物学功能.随着对白蛋白结构和功能的深入研究,有效白蛋白浓度概念引入,发现在慢性肝病患者中由于白蛋白的翻译后修饰,引起了结构上的改变从而使有效白蛋白浓度下降,且有效白蛋白浓度比总白蛋白更能准确地反映疾病进展,并为人血白蛋白输注提供更为准确的新指征.本文概述了白蛋白翻译后修饰与肝脏及相关疾病的临床关联性,并提供了有效白蛋白在临床实践中应用的循证证据,以期更好指导慢性肝病的临床治疗管理.Albumin is a non-glycosylated plasma protein.Besides the role of increasing blood volume and maintaining plasma colloid osmotic pressure,albumin also has multiple biological functions such as transport,antioxidant and anti-inflammatory effects,immune regulation,etc.In-depth studies on the structure and function of albumin have revealed that the post-transcriptional modification of albumin reduces the effective albumin concentration in patients with chronic liver disease,so the clinically effective albumin concentration rather than total albumin concentration can more accurately reflect the disease progression and prognosis,and more effectively guide exogenous albumin treatment in such patients.This article summarizes the clinical correlation between post-transcriptional modification of albumin and the liver and its related diseases,as well as the studies on effective albumin,in order to provide evidence-based information on effective albumin concentration and to better guide the clinical treatment of chronic liver disease.

关 键 词：人血白蛋白 有效白蛋白浓度 翻译后修饰 缺血修饰白蛋白 

分 类 号：R575[医药卫生—消化系统]