疏肝和胃降逆汤联合雷贝拉唑治疗肝胃不和证反流性食管炎患者的疗效  

Effect of Shugan Hewei Jiangni Decoction Combined with Rabeprazole in the Treatment of Reflux Esophagitis with Liver and Stomach Disharmony Syndrome

作　　者：林琦 毛文武 LIN Qi;MAO Wen-wu(Putian Hanjiang District Hospital of Traditional Chinese Medicine,Fujian Putian 351100;Gudong Street Community Health Service Center,Gulou District,Fujian Fuzhou 350000)

机构地区：[1]莆田市涵江区中医院,福建莆田351100 [2]福州市鼓楼区鼓东街道社区卫生服务中心,福建福州350000

出　　处：《深圳中西医结合杂志》2023年第2期40-43,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探究疏肝和胃降逆汤加减联合雷贝拉唑治疗肝胃不和证反流性食管炎(RE)患者的临床疗效。方法:选取莆田市涵江区中医院2021年2月至2022年2月期间收治的100例肝胃不和证RE患者,随机分为对照组与观察组,各50例。对照组患者采用雷贝拉唑、莫沙必利治疗,观察组患者采用疏肝和胃降逆汤加减联合雷贝拉唑治疗。比较两组患者的临床疗效、中医证候积分、血清相关指标及6个月复发率。结果:观察组患者治疗总有效率为94.00%,高于对照组的76.00%,差异具有统计学意义(P<0.05)。治疗后观察组患者各项中医证候积分低于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患者血清胃动素(MTL)、胃泌素(GAS)水平高于对照组,生长抑素(SS)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患者血清白细胞介素–1β(IL–1β)、IL–2、瘦素(Leptin)、降钙素基因相关肽(CGRP)水平低于对照组,差异具有统计学意义(P<0.05)。随访6个月,观察组失访4例,对照组失访3例。观察组患者6个月复发率为2.13%,低于对照组的18.42%,差异具有统计学意义(P<0.05)。结论:采用疏肝和胃降逆汤加减联合雷贝拉唑治疗RE,可促进患者胃肠道蠕动,提高胃肠道功能,抑制机体炎症因子表达,显著改善临床症状,从而提高临床疗效,降低复发风险。Objective To explore the clinical effect of Shugan Hewei Jiangni decoction combined with rabeprazole in the treatment of reflux esophagitis(RE)with liver and stomach disharmony syndrome.Methods A total of 100 cases of RE with liver and stomach disharmony syndrome patients admitted to Putian Hanjiang District Hospital of Traditional Chinese Medicine from February 2021 to February 2022 were randomly divided into a control group and an observation group,with 50 cases in each group.The control group was treated with rabeprazole and mosapride,and the observation group was treated with Shugan Hewei Jiangni decoction plus or minus combined with rabeprazole.The clinical efficacy,traditional Chinese medicine(TCM)syndrome score,serum related indexes and 6-month recurrence rate were compared between the two groups.Results The total effective rate of the observation group was 94.00%,higher than 76.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of TCM syndrome in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum motilin(MTL)and gastrin(GAS)in the observation group were higher than those in the control group,the level of somatostatin(SS)was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum interleukin-1β(IL-1β),IL-2,leptin and calcitonin gene-related peptide(CGRP)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 6 months of follow-up,4 cases were lost to follow-up in the observation group and 3 cases in the control group.The 6-month recurrence rate of the observation group was 2.13%,lower than 18.42%of the control group,and the difference was statistically significant(P<0.05).Conclusion Shugan Hewei Jiangni decoction plus or minus combined with rabeprazole in the treatment of RE can promote gast

关 键 词：反流性食管炎 肝胃不和证 疏肝和胃降逆汤 雷贝拉唑 

分 类 号：R571[医药卫生—消化系统]