Role of Cannabinoid CB1 Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats  

作　　者：Kaveh Shahveisi Seyedeh Marziyeh Hadi Hamed Ghazvini Mehdi Khodamoradi 

机构地区：[1]Sleep Disorders Research Center,Kermanshah University of Medical Sciences,Kermanshah 6719851451,Iran [2]Faculty of Medicine,Kermanshah University of Medical Sciences,Kermanshah 6714869914,Iran [3]Psychiatry and Behavioral Sciences Research Center,Addiction Institute,Mazandaran University of Medical Sciences,Sari 48175866,Iran [4]Department of Neuroscience,School of Advanced Technologies in Medicine,Mazandaran University of Medical Sciences,Sari 48175866,Iran [5]Substance Abuse Prevention Research Center,Health Institute,Kermanshah University of Medical Sciences,Kermanshah 6719851451,Iran

出　　处：《Chinese Medical Sciences Journal》2023年第1期29-37,共9页中国医学科学杂志（英文版）

基　　金：Supported by the Research Council of Kermanshah University of Medical Sciences,Kermanshah,Iran for financial support(grant no.:990812).

摘　　要：Objective We aimed to investigate whether antagonism of the cannabinoid CB1 receptor(CB1R)could affect novel object recognition(NOR)memory in chronically rapid eye movement sleep-deprived(RSD)rats.Methods The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform technique.The CB1R antagonist rimonabant(1 or 3 mg/kg,i.p.)was administered either at one hour prior to the sample phase for acquisition,or immediately after the sample phase for consolidation,or at one hour before the test phase for retrieval of NOR memory.For the reconsolidation task,rimonabant was administered immediately after the second sample phase.Results The RSD episode impaired acquisition,consolidation,and retrieval,but it did not affect the reconsolidation of NOR memory.Rimonabant administration did not affect acquisition,consolidation,and reconsolidation;however,it attenuated impairment of the retrieval of NOR memory induced by chronic RSD.Conclusions These findings,along with our previous report,would seem to suggest that RSD may affect different phases of recognition memory based on its duration.Importantly,it seems that the CB1R may,at least in part,be involved in the adverse effects of chronic RSD on the retrieval,but not in the acquisition,consolidation,and reconsolidation,of NOR memory.

关 键 词：REM sleep deprivation novel object recognition memory cannabinoid CB1 receptor RIMONABANT 

分 类 号：R285[医药卫生—中药学]