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作 者:彭睿 蒋冬先 任磊 王海星 徐磊 宿杰阿克苏 侯英勇 PENG Rui;JIANG Dong-xian;REN Lei;WANG Hai-xing;XU Lei;AKESU Su-jie;HOU Ying-yong(Department of Pathology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
机构地区:[1]复旦大学附属中山医院病理科,上海200032
出 处:《中国临床医学》2023年第1期85-90,共6页Chinese Journal of Clinical Medicine
基 金:国家自然科学基金(81702372);上海市临床专科建设项目(shslczdzk01302)。
摘 要:目的探讨微管不稳定蛋白stathmin在食管鳞状细胞癌中的表达水平及其与临床病理特征、预后的关系。方法收集2007年1月至2010年12月在复旦大学附属中山医院手术切除的496例食管鳞状细胞癌患者的临床病理资料,采用免疫组织化学法检测肿瘤组织stathmin的表达情况,分析其表达差异与患者临床病理特征和预后的关系。结果496例食管鳞状细胞癌患者中,266例为Ⅰ~Ⅱ期,230例为Ⅲ~Ⅳ期。Stathmin蛋白不表达、低表达和高表达的比例分别为2.4%、87.1%和10.5%。Stathmin高表达与肿瘤分化差相关(P=0.040)。生存分析发现:stathmin高表达组患者的无疾病生存期(disease free survival,DFS)和总生存期(overall survival,OS)与不表达/低表达组相比,有预后差的趋势,但差异无统计学意义(DFS:P=0.159;OS:P=0.176)。在Ⅰ~Ⅱ期患者中,stathmin高表达组比stathmin不表达/低表达组的预后差(DFS:P=0.032;OS:P=0.018);但是在Ⅲ~Ⅳ期患者中,stathmin高表达组与stathmin不表达/低表达组的预后差异无统计学意义(DFS:P=0.785;OS:P=0.613)。Ⅰ~Ⅱ期中stathmin高表达患者的预后,与Ⅲ~Ⅳ期stathmin不表达/低表达患者或者高表达患者差异无统计学意义。结论Ⅰ~Ⅱ期食管鳞状细胞癌中,stathmin高表达的患者预后差。Objective To explore stathmin(microtubule-destabilizing protein)expression and its correlation with clinicopathological characteristics and prognosis in esophageal squamous cell carcinoma(ESCC).Methods The clinicopathological parameters of 496 ESCC patients who underwent surgical resection between January 2007 and December 2010 in Zhongshan Hospital,Fudan University were collected.Stathmin protein expression was measured by immunohistochemistry(IHC),and its association with clinicopathological parameters and patients’outcome was analyzed.Results Of the 496 ESCC patients,266were in stageⅠ-Ⅱ,and 230 in stageⅢ-Ⅳ.The rates of stathmin no expression,low expression and high expression were 2.4%、87.1%and 10.5%,respectively.High stathmin expression was associated with poorer tumor differentiation(P=0.040).Survival analysis showed that there was a tendency of poorer disease free survival(DFS)and overall survival(OS)in ESCC patients with high stathmin expression,compared to those with low or no stathmin expression(DFS:P=0.159,OS:P=0.176).InⅠ-Ⅱstage,high stathmin expression was significantly correlated with poorer DFS(P=0.032)and OS(P=0.018).However,inⅢ-Ⅳstage,no survival difference was observed between high stathmin expression and low/no stathmin expression(DFS:P=0.785,OS:P=0.613).Moreover,the survival of stageⅠ-Ⅱpatients with high stathmin expression was identical to stageⅢ-Ⅳpatients with or without high stathmin expression.Conclusions In stageⅠ-ⅡESCC,high stathmin expression predicted poorer prognosis,and patients might been upstaged by high stathmin expression.
关 键 词:食管鳞状细胞癌 STATHMIN蛋白 肿瘤分期 预后
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