CAFs与肿瘤细胞的免疫逃逸机制  

CAFs and cancer immune evasion mechanism

作　　者：赵刚[1] 潘咏梅 黄岩松 张进 拉再提·哈扎依拜克 阿力古力·艾则孜 徐贵颖 ZHAO Gang;PAN Yongmei;HUANG Yansong;ZHANG Jin;LAZAITI Hazhayibaike;ALIGULI Aizezi;XU Guiying(School of Public Health,Jilin University,National Health Commission Key Laboratory of Radiobiology,Changchun 130021,China)

机构地区：[1]吉林大学公共卫生学院,国家卫生健康委员会放射生物学重点实验室,长春130021 [2]吉林省肿瘤医院乳腺二科,长春130000

出　　处：《中国免疫学杂志》2023年第3期653-656,共4页Chinese Journal of Immunology

基　　金：吉林省科技厅科技发展计划项目(20190201039JC);吉林省卫健委科研项目(2019J078)。

摘　　要：肿瘤相关成纤维细胞(CAFs)是肿瘤微环境(TME)中的一种重要组成,近年研究显示,CAFs与肿瘤细胞的免疫逃逸密切相关。肿瘤细胞的免疫逃逸是指肿瘤细胞通过多种机制逃避机体免疫系统识别和攻击,使其在体内生存和增殖的现象。本文分别从巨噬细胞、树突状细胞、髓系来源的抑制细胞、NK细胞和T细胞5种免疫细胞综述了CAFs如何与免疫细胞相互作用,最终介导了肿瘤细胞的免疫逃逸。Cancer-associated fibroblasts(CAFs)is an important component of tumour microenvironmen(t TME).Recent studies have shown that CAFs is closely related to immune evasion of tumor cells.The immune evasion of tumor cells refers to the phenomenon that tumor cells escape the recognition and attack of the immune system through various mechanisms,so as to survive and proliferate in vivo.This article reviews how CAFs interact with immune cells and ultimately mediate immune evasion of tumor cells from five immune cells,namely macrophages,dendritic cells,myeloid derived suppressor cells,NK cells and T cells.

关 键 词：肿瘤相关成纤维细胞 免疫逃逸 肿瘤 肿瘤微环境 

分 类 号：R735.7[医药卫生—肿瘤]