名老中医宋爱莉治疗乳腺癌骨转移用药规律分析  

nalysis of medication rule of famous old traditional Chinese medicine doctor Song Aili in the treatment of breast cancer bone metastasis

作　　者：许继升 宋爱莉[2] 浦冬青 王静 张靖誉 时光喜[2] 李静蔚[2] XU Jisheng;SONG Aili;PU Dongqing;WANG Jing;ZHANG Jingyu;SHI Guangxi;LI Jingwei(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250014,China;Department of Breast and Thyroid Surgery,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250014,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250014 [2]山东中医药大学附属医院乳腺甲状腺外科,山东济南250014

出　　处：《中国医药导报》2023年第9期131-134,143,共5页China Medical Herald

基　　金：山东省医药卫生科技发展计划项目(202104080463);山东省齐鲁卫生与健康领军人才项目(鲁卫人字〔2020〕3号)。

摘　　要：目的基于数据挖掘技术分析宋爱莉教授治疗乳腺癌骨转移的用药规律。方法收集2019年6月至2022年6月山东中医药大学附属医院宋教授门诊及住院诊治的乳腺癌骨转移患者服用的中药处方,运用中医传承辅助平台(V2.5)分析其用药频次、药物功效、四气、五味、归经及用药规律。结果筛选出中药处方145首,共涉及中药161味,用药频次居于前6味的是补骨脂、三七、枸杞子、黄芪、党参、莪术,药物类别以补肾、活血类药使用频率最高,药性以温、平为主,药味以甘、苦为主,归经以肝、脾、肾经为主,关联规则网络分析发现补骨脂、枸杞子、三七、白花蛇舌草、莪术、黄芪、党参、甘草、茯苓、当归10味药为宋教授治疗乳腺癌骨转移核心处方,基于熵聚类药物核心组合挖掘出潜在新方3个。结论宋教授治疗乳腺癌骨转移以“补肾活血,益气养血”为核心治法,辅以化痰祛湿、理气、解毒抗癌等药物治疗。Objective To analyze the medication rule of Professor Song Aili in the treatment of breast cancer bone metastasis based on data mining.Methods Traditional Chinese medicine prescriptions taken by breast cancer patients with bone metastases treated by Professor Song in the outpatient department and inpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from June 2019 to June 2022 were collected,and the traditional Chinese medicine inheritance support system(V2.5)was used to analyze the drug frequency,drug efficacy,four natures,five flavors,channel tropism,and drug use regularity.Results A total of 145 traditional Chinese medicine prescriptions were screened,involving 161 traditional Chinese medicine.The top six drug use frequency were Psoraleae Fructus,Notoginseng Radix Et Rhizoma,Lycii Fructus,Astragali Radix,Codonopsis Radix and Curcumae Rhizoma.The frequency of drug use was highest in tonifying kidney and promoting blood circulation drugs.The drug natures were mainly warm and flat,the drug flavors were mainly sweet and bitter,and the channel tropisms were mainly liver,spleen,and kidney channels.Association rule network analysis showed that ten drugs including Psoraleae Fructus,Lycii Fructus,Notoginseng Radix Et Rhizoma,Hedyotis diffusa Willd.,Curcumae Rhizoma,Astragali Radix,Codonopsis Radix,Glycyrrhizae Radix Et Rhizoma,Poria,and Angelicae Sinensis Radix were the core prescriptions for Professor Song’s treatment of breast cancer bone metastases.Three potential new prescriptions were discovered based on entropy clustering core combination of drugs.Conclusion In the treatment of breast cancer bone metastasis,Professor Song takes“tonifying kidney and promoting blood circulation,invigorating qi and nourishing blood”as the core treatment,supplemented by dissipating phlegm and eliminating dampness,regulating qi-flowing,detoxificationk,anti-cancer and other drugs.

关 键 词：乳腺癌骨转移 名老中医 宋爱莉 数据挖掘 用药经验 

分 类 号：R737.9[医药卫生—肿瘤]