阿立哌唑与氟哌啶醇联合心理行为干预治疗儿童抽动障碍的效果比较  

Comparison of effects of Aripiprazole and Haloperidol combined with psychological and behavioral intervention on children with tic disorder

作　　者：史运强 SHI Yunqiang(Department of Pediatrics of Fan County People’s Hospital,Puyang 457500 Henan,China)

机构地区：[1]范县人民医院儿科,河南濮阳457500

出　　处：《中国民康医学》2023年第5期159-161,165,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较阿立哌唑与氟哌啶醇联合心理行为干预治疗儿童抽动障碍的效果。方法:选取2020年1—12月该院收治的78例儿童抽动障碍进行前瞻性研究,按随机数字表法将其分为对照组(n=39)与研究组(n=39)。两组均给予心理行为干预,在此基础上,对照组采用氟哌啶醇片治疗,研究组采用阿立哌唑片治疗,比较两组临床疗效、治疗前后耶鲁抽动严重程度量表(YGTSS)评分、神经递质[γ-氨基丁酸(GABA)、多巴胺(DA)、5-羟色胺(5-HT)]水平和不良反应发生率。结果:研究组治疗总有效率为94.87%(37/39),高于对照组的71.79%(28/49),差异有统计学意义(P<0.05);治疗后,两组YGTSS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组DA、5-HT水平均低于治疗前,且研究组低于对照组,两组GABA水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿立哌唑联合心理行为干预应用于儿童抽动障碍可提高治疗总有效率,改善神经递质水平,降低YGTSS评分,其效果优于氟哌啶醇片联合心理行为干预。Objective:To compare effects of Aripiprazole and Haloperidol combined with psychological and behavioral intervention on children with tic disorder.Methods:A prospective study was conducted on 78 children with tic disorder admitted to the hospital from January to December 2020.They were divided into control group(n=39)and study group(n=39)according to the random number table method.Both groups were given psychological and behavioral intervention.On this basis,the control group was treated with Haloperidol tablets,while the study group was treated with Aripiprazole tablets.The clinical efficacy,the score of Yale global tic severity scale(YGTSS),the neurotransmitter index[γ-Aminobutyric acid(GABA),dopamine(DA),5-hydroxytryptamine(5-HT)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 94.87%(37/39),which was higher than 71.79%(28/49)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the YGTSS scores of the two groups were lower than that before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).The DA and 5-HT levels in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the levels of GABA in both groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Aripiprazole combined with psychological and behavioral intervention in the children with tic disorder can improve the total effective rate of treatment,improve the levels of neurotransmitter indexes and reduce the YGTSS scores.Moreover,it is superior to Haloperidol tablets combined w

关 键 词：儿童抽动障碍 阿立哌唑 氟哌啶醇 心理行为干预 耶鲁抽动严重程度量表 神经递质 不良反应 

分 类 号：R749.94[医药卫生—神经病学与精神病学]