经口内镜下贲门缩窄术和泮托拉唑钠肠溶胶囊联合枸橼酸莫沙必利片治疗胃食管反流病的临床疗效对比  

Comparison of clinical efficacy of transoral endoscopic cardia constriction and pantoprazole sodium enteric capsule combined with mosapride citrate in the treatment of gastroesophageal reflux disease

作　　者：曾权祥 吴振华[1] 李景森[1] 王桢桢 Zeng Quanxiang;Wu Zhenhua;Li Jingsen;Wang Zhenzhen(Maoming People's Hospital,Maoming,Guangdong 525000,China)

机构地区：[1]广东省茂名市人民医院,广东茂名525000

出　　处：《首都食品与医药》2023年第6期55-58,共4页Capital Food Medicine

基　　金：茂名市科学技术局科技计划项目(项目编号:190408151701751)。

摘　　要：目的对比经口内镜下贲门缩窄术和泮托拉唑钠肠溶胶囊联合枸橼酸莫沙必利片治疗胃食管反流病的临床疗效。方法回顾性分析2019年5月9日-2021年5月10日茂名市人民医院收治的45例胃食管反流病患者临床诊治资料,按照治疗方法的不同分为手术组(n=21,经口内镜下贲门缩窄术)和药物组(n=24,泮托拉唑钠肠溶胶囊联合枸橼酸莫沙必利片),对比两组症状消失时间、临床疗效、治疗前后疾病对生活的影响及治疗安全性。结果手术组烧心感、反酸反流、吞咽困难、上腹部烧灼感及胸骨后疼痛等症状消失时间短于药物组(P<0.05);手术组疗效高于对照组(P<0.05);治疗后手术组GERD-QOL评分低于药物组(P<0.05);手术组术后并发症发生率(4.76%)低于药物组不良反应发生率(12.5%),但组间差异无统计学意义(χ2=0.828,P=0.362,P>0.05)。结论对比经口内镜下贲门缩窄术和泮托拉唑钠肠溶胶囊联合枸橼酸莫沙必利片治疗胃食管反流病的临床疗效发现,两种治疗方案在治疗安全性方面无显著差异,但经口内镜下贲门缩窄术的短期疗效优于泮托拉唑钠肠溶胶囊联合枸橼酸莫沙必利片治疗,可较快缓解患者临床症状和减轻疾病对患者日常生活的不良影响。Objective To compare the clinical efficacy of transoral endoscopic cardia constriction and pantoprazole sodium enteric capsule combined with mosapride citrate in the treatment of gastroesophageal reflux disease.Methods The clinical data of 45 patients with gastroesophageal reflux disease admitted to our hospital from May 9,2019 to May 10,2021 were retrospectively analyzed.According to the different treatment methods,they were divided into operation group(n=21,transoral endoscopic cardia constriction)and drug group(n=24,pantoprazole sodium enteric capsule combined with mosapride citrate).The disappearance time of symptoms,clinical efficacy,impact of disease on life before and after treatment and treatment safety were compared between the two groups.Results The disappearance time of heartburn,acid reflux,dysphagia,upper abdominal burning and retrosternal pain in the operation group was shorter than that in the drug group(P<0.05).The curative effect of operation group was higher than that of control group(P<0.05).After treatment,GERD-QOL score of surgery group was lower than that of drug group(P<0.05).The incidence of postoperative complications in the surgery group(4.76%)was lower than that in the drug group(12.5%),but there was no significant difference between the two groups(χ2=0.828,P=0.362,P>0.05).Conclusion Contrast transoral endoscopic cardiac narrow and diazepam tora azole sodium enteric capsules joint citrate moser will benefit the clinical curative effect of treatment of gastroesophageal reflux disease,found that two types of treatment there was no significant difference in the treatment of security,but through the mouth of endoscopic cardiac the short-term efficacy of relatively narrow is better than that of panxi tora azole sodium enteric capsules joint citrate moser will the treatment,it can quickly relieve the clinical symptoms and reduce the adverse effects of the disease on the daily life of patients.

关 键 词：经口内镜下贲门缩窄术 泮托拉唑钠肠溶胶囊 枸橼酸莫沙必利 胃食管反流病 

分 类 号：R571[医药卫生—消化系统]