仿生矿化胶原材料应用于引导骨再生术的研究进展  

Research progress on biomimetic mineralized collagen materials used in guided bone regeneration

作　　者：马士卿 王晓婧(综述) 彭诚(审校)[1] MA Shiqing;WANG Xiaojing;PENG Cheng(Department of Stomotology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China;College of Stomatology,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学第二医院口腔科,300211 [2]天津医科大学口腔医学院,300070

出　　处：《重庆医学》2023年第7期1072-1077,共6页Chongqing medicine

基　　金：国家自然科学基金项目(81701019)。

摘　　要：以仿生学为指导研发的仿生矿化胶原材料具有优异的生物可吸收性、骨传导性和明显高于传统胶原材料的机械强度。在生物活性因子的修饰下,它们还能够激活相关信号通路、调节成骨相关基因表达、诱导干细胞的成骨分化。仿生矿化胶原材料通常以屏障膜的形式在引导性骨再生(GBR)术中广泛应用,并凭借其良好的生物可吸收性和较少的术后并发症而逐渐取代传统的不可吸收膜。本文回顾了胶原蛋白矿化的基本原理,并详细论述了仿生矿化胶原材料在临床GBR术中的应用策略。Biomimetic mineralized collagen materials developed under the guidance of bionics represent excellent biological absorbability,osteoconduction and mechanical strength significantly higher than traditional collagen materials.With the modification of bioactive factors,they can also activate relevant signal pathways,regulate the expression of osteogenic genes,and induce the osteogenic differentiation of stem cells.Biomimetic mineralized collagen materials are widely used in guided bone regeneration(GBR)in the form of barrier membrane,and gradually replace the traditional non-absorbable membrane due to their good bioabsorbability and fewer postoperative complications.This paper reviewed the basic principle of collagen mineralization,and discussed the application strategies of biomimetic mineralized collagen materials in clinical GBR in detail.

关 键 词：胶原 仿生矿化 引导性骨再生 颌面骨缺损 

分 类 号：R782.13[医药卫生—口腔医学]