慢性间歇性限制摄食对大鼠恐惧记忆维持的影响  

Effects of chronic intermittent food restriction on the maintenance of fear memory in rats

作　　者：李颜行 孟适秋[2] 王汉卿 唐紫莹 薛言学[2] 吴萍 LI Yan-hang;MENG Shi-qiu;WANG Han-qing;TANG Zi-ying;XUE Yan-xue;WU Ping(Department of Pharmacology,School of Basic Medicine,Peking University,Beijing 100191,China;National Institute on Drug Dependence,Peking University,Beijing Key Laboratory of Drug Dependence Research,Bejing 100191,China)

机构地区：[1]北京大学基础医学院药理系,北京100191 [2]北京大学中国药物依赖性研究所,药物依赖性研究北京市重点实验室,北京100191

出　　处：《中国药物依赖性杂志》2023年第1期27-32,共6页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金项目(81201032)。

摘　　要：目的研究慢性间歇性限制摄食对大鼠条件性恐惧记忆维持和焦虑样行为的影响。方法雄性SD大鼠接受听觉条件性恐惧记忆训练,随后进行为期4周的间歇性限制摄食;之后进行恐惧记忆、高架迷宫和自发活动测试。结果与正常摄食组大鼠相比,限制摄食4周大鼠的听觉恐惧记忆水平显著降低,进入高架迷宫开放臂的次数和时间显著增加,提示限制摄食降低恐惧记忆的维持,且降低动物的焦虑水平。结论限制摄食能够降低恐惧记忆的维持,为治疗恐惧记忆相关疾病提供了新的思路。Objective To investigate the effects of chronic intermittent food restriction on the maintenance of conditioned fear memory and anxiety-like behavior in rats.Methods Male SD rats received auditory conditioned fear memory training,followed by intermittent food restriction for 4 weeks.Subsequently,the fear memory,elevated plus maze,open field and locomotor activity tests were performed.Results Compared with the rats in the control group,the freezing of rats in the food restriction group was significantly reduced,and the number and time entering the open arms in the elevated maze were significantly increased,suggesting that food restriction reduced the maintenance of fear memory and anxiety-like behaviors.Conclusion Chronic restricted food intake can reduce the maintenance of fear memory,which provides a new avenue for the treatment of fear memory-related disorders.

关 键 词：恐惧记忆 限制摄食 维持 焦虑样行为 

分 类 号：R749[医药卫生—神经病学与精神病学]