山东某精神专科医院酒精所致精神障碍的精神疾病共病及相关因素  

Comorbidity and related factors of mental disorders caused by alcohol in a psychiatric hospital in Shandong Province

作　　者：张秋雨 魏辰 杨蕾 孔祥娟 肖心怡 苏中华 ZHANG Qiu-yu;WEI Chen;YANG Lei;KONG Xiang-juan;XIAO Xin-yi;SU Zhong-hua(Jining Medical College,Jining 272067,Shandong,China;Shandong Daizhuang Hospital,Jining 272051,Shandong,China)

机构地区：[1]济宁医学院,山东济宁272067 [2]山东省戴庄医院,山东济宁272051

出　　处：《中国药物依赖性杂志》2023年第1期65-70,共6页Chinese Journal of Drug Dependence

基　　金：山东省医药卫生科技发展计划项目(202003090418)。

摘　　要：目的本文回顾性分析了山东省戴庄医院2011年-2019年间酒精所致精神障碍与其他精神障碍的共病率,分析其共病的相关因素。方法以研究单位2011年10月至2019年12月出院的酒精所致精神障碍2740例患者为研究对象,根据是否患共病其他精神障碍,将研究对象分为共病组(n=384例)和非共病组(n=2356例),比较两组患者的人口学和临床特征差异,通过二分类Logistic分析探讨酒精所致精神障碍共病其他精神障碍的主要危险因素。结果酒精所致精神障碍共病其他精神障碍共病率为14.0%(384/2740),精神分裂症占27.6%;双相情感障碍占25.8%;抑郁障碍占24.5%;其他共病精神障碍占22.1%。共病组患者女性(χ^(2)=8.283,P=0.008)、汉族(χ^(2)=10.606,P=0.003)、有害性使用(χ^(2)=181.965,P<0.001)、无戒断状态(χ^(2)=51.553,P<0.001)、无伴有谵妄的戒断状态(χ^(2)=22.750,P<0.001)、无精神病性障碍(χ^(2)=38.389,P<0.001)、与餐同饮(χ^(2)=8.620,P=0.004)、无晨饮(χ^(2)=209.504,P<0.001)、无睡前饮酒(χ^(2)=130.584,P<0.001)、合并躯体疾病个数(χ^(2)=-18.275,P<0.001)、住院次数2~4次(χ^(2)=52.669,P<0.001)、住院天数(χ^(2)=-6.212,P<0.001)等特征,与非共病组相比差异有统计学意义。二分类Logistic分析结果表明,有害性使用、多次住院、合并躯体疾病与共病其他精神障碍正关联;戒断状态、伴有谵妄的戒断状态、精神病性障碍、晨饮与共病负关联。结论精神专科医院中,存在有害性使用、多次住院的酒精所致精神障碍患者更多共病其他精神障碍;存在戒断状态、伴有谵妄的戒断状态、精神病性障碍、晨饮、合并躯体疾病的酒精患者相对较少共病其他精神障碍。重点关注共病的危险因素,有利于早期识别、积极治疗酒精共病其他精神障碍。Objective To retrospectively analyze the comorbidity rate of alcohol-induced mental disorders and other mental disorders in Shandong Daizhuang Hospital from 2011 to 2019,and to analyze the related factors of comorbidity.Methods The total of 2740 patients with alcohol-induced mental disorders discharged from the research unit from October 2011 to December 2019 were taken as the subjects.According to the comorbid with other mental disorders,the subjects were divided into comorbid group(n=384)and non-comorbid group(n=2356).The differences of demographic and clinical characteristics between groups were compared to explore the main risk factors of comorbidity by Binary logistic analysis.Results The comorbidity rate of alcohol-induced mental disorders and other mental disorders was 14.0%(384/2740),and schizophrenia accounted for 27.6%,respectively.Bipolar disorder accounted for 25.8%,depression accounted for 24.5%,and other comorbid mental disorders accounted for 22.1%.Compared with the non-comorbid group,patients in the comorbid group were female(χ^(2)=8.283,P=0.008),Han nationality(χ^(2)=10.606,P=0.003),harmful use(χ^(2)=181.965,P<0.001),no withdrawal(χ^(2)=51.553,P<0.001),no withdrawal state with delirium(χ^(2)=22.750,P<0.001),no psychotic disorder(χ^(2)=38.389,P<0.001),drink with meal(χ^(2)=8.620,P=0.004),no morning drink(χ^(2)=209.504,P<0.001),no drinking before going to bed(χ^(2)=130.584,P<0.001)and number of somatic diseases(χ^(2)=-18.275,P<0.001).The number of hospitalizations was 2-4(χ^(2)=52.669,P<0.001),length of stay(χ^(2)=-6.212,P<0.001)the difference was statistically significant(test levelα=0.05).The results of Binary logistic analysis showed that harmful use,multiple hospitalization and physical diseases were positively correlated with comorbidity.Withdrawal state,withdrawal state with delirium,psychotic disorder,morning drinking were negatively correlated with comorbidity.Conclusion There are more comorbidities and other mental disorders in psychiatric hospitals.Alcohol patients with withd

关 键 词：酒精所致精神障碍 共病 其他精神障碍 共病率 有害性使用 戒断状态 住院次数 

分 类 号：R749[医药卫生—神经病学与精神病学]