Buckle up! How the nano-seatbelt MRAP1 fastens ACTH in its orthosteric seat  

作　　者：Daniel Hilger 

机构地区：[1]Department of Pharmaceutical Chemistry,Philipps-University Marburg,Marburg,Germany

出　　处：《Cell Research》2023年第3期191-192,共2页细胞研究（英文版）

摘　　要：Specific binding of the adrenocorticotropic hormone(ACTH)to the melanocortin-2 receptor(MC2R)requires the presence of the melanocortin-2 receptor accessory protein 1(MRAP1)to induce stress responses via adrenal synthesis and secretion of glucocorticoids.In a recent study published in Cell Research,Luo et al.determined the cryo-EM structure of the ACTH-bound MC2R in complex with the heterotrimeric G protein Gs and MRAP1,which provides important new insights into the molecular mechanism of accessory protein-dependent regula-tion of ligand binding and signaling of G protein-coupled receptors.

关 键 词：STERIC synthesis INSIGHT 

分 类 号：O62[理学—有机化学]