Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection  

作　　者：Bo Gao Liheng He Yujie Bao Yingying Chen Guanzhu Lu Yu Zhang Yingjie Xu Bing Su Jie Xu Ying Wang Leng-Siew Yeap 

机构地区：[1]Shanghai Institute of Immunology,Department of Immunology and Microbiology,State Key Laboratory of Oncogenes and Related Genes,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Center for Immune-Related Diseases at Shanghai Institute of Immunology,Department of Endocrinology and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [3]Department of Infectious Diseases,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]Shanghai Key Laboratory of Emergency Prevention,Diagnosis and Treatment of Respiratory Infectious Diseases(20dz2261100),Shanghai,China [5]Key Laboratory of Parasite and Vector Biology,Ministry of Health,School of Global Health,Chinese Center for Tropical Diseases Research,Shanghai Jiao Tong University School of Medicine,Shanghai,China [6]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation,Department of Biochemistry and Molecular Cell Biology,Shanghai Jiao Tong University School of Medicine,Shanghai,China [7]Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism,Shanghai Jiao Tong University School of Medicine,Shanghai,China [8]Shanghai Institute of Virology,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《Cell Research》2023年第3期258-261,共4页细胞研究（英文版）

基　　金：This work was supported by funds from the National Key R&D Program of China(2021YFA1301400 to B.S.,Y.X.,L.-S.Y.,and 2021YFC2301500 to Y.W.);the National Natural Science Foundation of China(31722020 to L.-S.Y.,31930035,91942311 and 32061143028 to B.S.);Shanghai Science and Technology Commission(20410714000,20JC410100 and 22JC1402600 to B.S.).

摘　　要：Dear Editor,Since the emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019,the virus has continued to evolve resulting in new waves of infection and immune escape in the vaccinated population.1 The Omicron strains belong to newly prevailing variants of concern(VOCs).They acquired as many as 30 mutations in the spike(S)gene and half of which occur at the receptor-binding domain(RBD)of the S protein.Moreover,the Omicron variants can evade neutralization activity by most of the identified anti-SARS-CoV-2 antibodies.2,3 Several reports have suggested that three-dose vaccination mounted better neutraliz-ing activity against Omicron than two-dose vaccination.

关 键 词：VACCINATION ANTIBODIES INFECTION 

分 类 号：R563.1[医药卫生—呼吸系统]