Supramolecular Template-Assisted Catalytic[2+2]Photocycloaddition in Homogeneous Solution  

作　　者：Fang Wang Sha Bai Qing-Wen Zhu Zi-Hang Wei Ying-Feng Han 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education,Xi’an Key Laboratory of Functional Supramolecular Structure and Materials,College of Chemistry and Materials Science,Northwest University,Xi’an 710127

出　　处：《CCS Chemistry》2023年第3期633-640,共8页中国化学会会刊（英文）

基　　金：Financial support from the National Natural Science Fund for Distinguished Young Scholars of China(grant no.22025107);the National Youth Top-notch Talent Support Program of China,the Key Science and Technology Innovation Team of Shaanxi Province(grant nos.2019TD-007 and 2019JLZ-02);the FM&EM International Joint Laboratory of Northwest University is gratefully acknowledged.

摘　　要：Supramolecular interactions can help recognize and organize substrates around an enzyme’s active sites and subsequently assemble a new molecule in a certain way.Inspired by nature’s control of reactions,in this work we designed a template catalyst equipped with ditopic Au(I)–N-heterocyclic carbene(NHC)functional sites that direct olefin substrates into reactive geometries via collaboration of coordination-driven interactions.Notably,this catalyst enables the realization of catalytic[2+2]photocycloadditions with as low as 2 mol%catalyst loading in homogeneous solution and the delivery of a series of cyclobutane derivatives with excellent conversions and stereoselectivities.The success of gram-scale reactions further demonstrates the feasibility of this strategy,which lays a solid foundation for the large-scale preparation of cyclobutane derivatives in the future.

关 键 词：N-heterocyclic carbene supramolecular catalysis template synthesis PHOTOCYCLOADDITION SELF-ASSEMBLY 

分 类 号：O641.3[理学—物理化学] O643.36[理学—化学]