Microtubules are essential for angiogenic sprout elongation in zebrafish  

作　　者：Chuan Wu Da Zhang Jingying Chen 

机构地区：[1]Institute of Developmental Biology and Regenerative Medicine,Southwest University,Beibei,Chongqing 400715,China [2]University of Chinese Academy of Sciences(Chongqing),Chongqing Institute of Green and Intelligent Technology,Chinese Academy of Sciences,Beibei,Chongqing 400714,China

出　　处：《Journal of Genetics and Genomics》2023年第2期126-129,共4页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China,China(32000576);the Natural Science Foundation of Chongqing,China(cstc2020jcyj-msxmX0882).

摘　　要：Angiogenesis is a process in which newborn vessels sprout from preexisting blood vessels(Isogai et al.,2003;Geudens and Gerhardt,2011;Herbert and Stainier,2011;Chen et al.,2019,2021),and the dynamic changes of the cytoskeleton system are important for angiogenesis.A previous study revealed that although F-actin polymerization is required for filopodia formation,impairing filopodia formation by disturbing F-actin polymerization only resulted in the slow growth of angiogenic sprouts in zebrafish(Phng et al.,2013).Therefore,F-actin may not be essential for angiogenic sprout elongation.Many studies have shown that microtubules also participate in angiogenesis(Myers et al.,2011;Ganguly et al.,2013;Martin et al.,2018).Due to the lack of in vivo real-time imaging,the role of microtubules in angiogenic sprout elongation remains unclear.

关 键 词：angiogenic ANGIOGENESIS 

分 类 号：Q952[生物学—动物学]