川芎清脑颗粒治疗慢性脑缺血伴头痛的疗效研究  

Efficacy and safety of Chuanxiong Qingnao Granules in the treatment of headache in chronic cerebral ischemia

作　　者：王丽华[1] 杨弋[2] 周德生[3] 唐亚梅[4] 李会敏[5] WANG Li-hua;YANG Yi;ZHOU De-sheng;TANG Ya-mei;LI Hui-min(Department of Neurology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;不详)

机构地区：[1]哈尔滨医科大学附属第二医院神经内科,黑龙江哈尔滨150086 [2]吉林大学第一医院神经内科,吉林长春130021 [3]湖南中医药大学第一附属医院神经内科,湖南长沙410208 [4]中山大学孙逸仙纪念医院神经科,广东广州510120 [5]河北大学附属医院神经内科,河北保定071000

出　　处：《中国实用内科杂志》2023年第1期74-77,共4页Chinese Journal of Practical Internal Medicine

摘　　要：目的 比较川芎清脑颗粒治疗慢性脑缺血伴头痛的疗效。方法 选择2017年1月1日至2019年12月31日哈尔滨医科大学附属第二医院等5家医院诊治的慢性脑缺血伴头痛患者224例作为研究对象。采用随机数字分组法将患者分成对照组和试验组(各112例)。两组患者均接受基础治疗,包括控制血压和对症等治疗,均给予阿司匹林口服100 mg,1次/d。对照组患者使用吡拉西坦治疗,口服0.8 mg,1次/d,连续治疗2个月。试验组患者口服川芎清脑颗粒治疗,10 g/次,3次/d,连续治疗2个月。在治疗前后比较两组患者疼痛情况、认知功能、头痛频次、临床疗效。结果 治疗前两组患者VAS评分差异比较无统计学意义(P>0.05)。在治疗1个月和2个月后试验组患者VAS评分(2.51±0.12,1.87±0.17)均低于对照组(P<0.05)。治疗前两组患者MoCA评分差异比较无统计学意义(P>0.05)。在治疗1个月和2个月后试验组患者MoCA评分(24.69±4.65,28.65±4.15)均高于对照组(P<0.05)。在治疗1个月和2个月后试验组患者头痛频次(1.69±0.41,0.68±0.12)低于对照组(P<0.05)。试验组临床总有效率明显高于对照组(P<0.05)。结论 川芎清脑颗粒治疗慢性脑缺血伴头痛可以明显提升临床疗效,改善患者头痛症状、减少头痛次数、保护患者认知功能。Objective To compare the efficacy and safety of Chuanxiong Qingnao granules in the treatment of headache in chronic cerebral ischemia.Methods A sample of 224 cases with chronic cerebral ischemia and headache in the five hospitals from January 1,2017 to December 31,2019 were randomly selected,and divided into two groups by random number table methods,each with 112 cases.Both groups received routine treatment including blood pressure control,symptomatic treatment and aspirin(100 mg qd).Based on this,control group received piracetam(0.8 mg,qd),while experimental group received Chuanxiong Qingnao granules(10 g,tid).Treatment in both groups lasted for 2 months.Then comparison was conducted on pain degree,cognitive function,headache frequency,clinical efficacy.Results Visual Analogue Scale(VAS)score demonstrated no significant difference between the two groups at the baseline(P>0.05),and the scores at post-treatment 1 and 2 months were(2.51 ± 0.12)and(1.87 ± 0.17)in experimental group,which were significantly lower than those of control group(P<0.05).Montreal Cognitive Assessment(MoCA)scores at post-treatment 1and 2 months were(24.69±4.65)and(28.65±4.15)in experimental group,which were significantly higher than those of control group(P<0.05).The headache frequency at post-treatment 1 and 2 months was(1.69±0.41)and(0.68±0.12)times in experimental group,which were significantly less than that of control group(P<0.05).The clinical efficacy rate was significantly higher in experimental group than in control group,with statistical difference(P<0.05).Conclusion Application of Chuanxiong Qingnao granules in the treatment of headache in chronic cerebral ischemia can effectively and safely ameliorate the headache symptoms,reduce the attack frequency and protect the cognitive function.

关 键 词：川芎清脑颗粒 慢性脑缺血 头痛 疗效 认知功能 疼痛 

分 类 号：R743[医药卫生—神经病学与精神病学]