重性抑郁障碍患者与其健康兄弟姐妹静息态脑局部一致性比较  

Comparation of resting brain regional homogeneity between patients with major depressive disorder and their healthy siblings

作　　者：李峰 张志芳 张保华 董芳 赵蕾 陈真竹 李田 王怡梦 薄奇静 王传跃 Li Feng;Zhang Zhifang;Zhang Baohua;Dong Fang;Zhao Lei;Chen Zhenzhu;Li Tian;Wang Yimeng;Bo Qijing;Wang Chuanyue(The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京100088

出　　处：《中华行为医学与脑科学杂志》2023年第3期225-230,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81901355)。

摘　　要：目的:探讨重性抑郁障碍(major depressive disorder,MDD)患者与其健康兄弟姐妹之间脑局部一致性(regional homogeneity,ReHo)的差异。方法:2013年1—12月采集87例MDD患者及21例患者健康兄弟姐妹的静息态功能磁共振(functional magnetic resonance imaging,fMRI)数据。采用DPABI v5.1软件对静息态fMRI数据进行预处理,并在个体水平上计算每个受试者的ReHo图谱。采用双样本t检验,在全脑水平上比较MDD患者和健康兄弟姐妹之间ReHo值的差异。将差异有统计学意义的脑区内的ReHo值进行提取,采用Spearman相关分析分别计算MDD患者与健康兄弟姐妹的ReHo值和17-汉密尔顿抑郁量表(17-items Hamilton depression rating scale,HAMD-17)总分的相关性。统计软件为SPSS 20.0。结果:与患者的健康兄弟姐妹相比,MDD患者在楔前叶向后扣带回皮层延伸的脑区(precuneus extending to the posterior cingulate cortex,PCu/PCC)表现出ReHo值的降低(团块大小=126体素,团块水平P_(FDR)=0.033;peak点MNI坐标:x=-4,y=-58,z=38,t=4.30)。在MDD患者中,PCu/PCC的ReHo值与HAMD-17项总分之间呈正相关(r=0.255,P=0.021)。结论:MDD患者较其健康兄弟姐妹在PCu/PCC的局部脑功能活动降低,且与抑郁症状严重程度相关,有助于进一步揭示MDD的内在神经机制。Objective To explore differences of resting brain regional homogeneity(ReHo)between patients with major depressive disorder(MDD)and their siblings.Methods From January to December 2013,the resting-state functional magnetic resonance imaging(fMRI)data of 87 patients with MDD and 21 healthy siblings were collected.DPABI v5.1 software was used to preprocess the resting-state fMRI data,and ReHo maps of each subject was obtained.A two-sample t-test was used to compare differences between the patients with MDD and their siblings in ReHo values throughout the brain.ReHo values within the significant brain regions were extracted out,and used to calculate Spearman correlation with the total score of 17-items Hamilton depression rating scale(HAMD-17)in the patients with MDD and their siblings respectively.The software of SPSS 20.0 was used for statistical analysis.Results The patients with MDD exhibited lower ReHo values in the precuneus extending to the posterior cingulate cortex(PCu/PCC)compared with their siblings(cluster-size=126 voxel,cluster-level P_(FDR)=0.033;MNI:x=-4,y=-58,z=38,t=4.30).ReHo values of the PCu/PCC in patient with MDD were positively correlated with the severity of depressive symptoms(r=0.255,P=0.021).Conclusion Compared with the siblings,local brain activity of the PCu/PCC in the patients with MDD was decreased,and related to the severity of depressive symptoms.It is helpful to further reveal the intrinsic neural mechanism of MDD.

关 键 词：重性抑郁障碍 健康兄弟姐妹 静息态 功能磁共振成像 局部一致性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]