酶型生物改性抗菌材料的研究进展  

Research progress on enzymatic modification of antibacterial materials

作　　者：唐亚丽 王立苹 卢立新 潘嘹 丘晓琳 TANG Yali;WANG Liping;LU Lixin;PAN Liao;QIU Xiaolin(School of Mechanical Engineering,Jiangnan University,Wuxi 214122,Jiangsu,China;Jiangsu Key Laboratory of Advance Food Manufacturing Equipment&Technology,Wuxi 214122,Jiangsu,China)

机构地区：[1]江南大学机械工程学院,江苏无锡214122 [2]江苏省先进食品制造装备技术重点实验室,江苏无锡214122

出　　处：《精细化工》2023年第3期465-477,共13页Fine Chemicals

基　　金：国家自然科学基金(31671909)。

摘　　要：细菌微生物感染是食品、药品、生物医疗等研究领域亟待解决的难题。抗生素的出现缓解了人们对抗菌材料的需求,但也导致耐药细菌的产生。因此,开发具有抗菌活性强、生物安全性高的天然抗菌剂和抗菌材料非常有意义。目前,抗菌酶在医疗机械、食品、药品、化妆品等领域具有广泛的应用前景,用于对抗微生物和生物膜的形成具有研究意义。该文综述了几种常见的酶型生物改性抗菌材料用的抗菌酶和抗菌酶系统,以及将抗菌酶与材料结合得到的酶型释放杀菌材料和酶型接触杀菌材料的研究进展,并对酶型生物改性抗菌材料的未来研究方向进行了总结和展望。Bacterial infection is a difficult problem urgently needed to be solved in the field of food,medicine and biomedics.The discovery of antibiotics has alleviated the demand for antimicrobial materials,but also led to the emergence of drug-resistant bacteria.Therefore,it is of great significance to develop natural antimicrobial agents and antibacterial materials with strong antibacterial activity and high biological safety.At present,antibacterial enzyme shows promising application potential in medical machinery,food,medicine,cosmetics and so on,and it is of research significance to employ them against the formation of microorganisms and biofilms.Herein,several common antibacterial enzymes and enzyme systems were introduced,followed by discussions on the research progress in combining antimicrobial enzymes with materials to produce enzyme release bactericidal materials and enzymatic contact bactericidal materials.Finally,the future development of enzyme modified antibacterial materials was summarized and prospected.

关 键 词：抗菌酶 生物改性 抗菌材料 固定化酶 抗菌性能 

分 类 号：Q814[生物学—生物工程] TB34[一般工业技术—材料科学与工程]