SPECT/CT骨定量标准化摄取值分析脊柱骨转移瘤的价值  

Significance of bone standardized uptake value of SPECT/CT for analyzing spinal metastases

作　　者：贾明胜 郑修竹 刘佳 陈逸如 杨慧 李长勤 JIA Ming-sheng;ZHENG Xiu-zhu;LIU Jia;CHEN Yi-ru;YANG Hui;LI Chang-qin(Department of Medical lmaging,The Second Affiliated Hospital,Shandong First Medical Unicersisy,Tai'an 271000,China)

机构地区：[1]山东第一医科大学第二附属医院医学影像科,山东泰安271000

出　　处：《中国矫形外科杂志》2023年第5期408-412,共5页Orthopedic Journal of China

基　　金：山东省医药卫生科技发展计划项目(编号:202209040961)。

摘　　要：[目的]探讨SPECT/CT骨定量标准化摄取值(standardized uptake value,SUV)分析对脊柱骨转移瘤的价值。[方法]回顾性分析2020年7月—2021年12月本院54例脊柱骨转移确诊患者的^(99m)Tc-MDP SPECT/CT骨显像资料。比较不同性别间正常椎体SUV差异;分析正常椎体SUV与身体参数相关性;比较正常骨与病灶之间、不同原发肿瘤病灶之间、边缘清晰与不清晰病灶之间SUV差异。采用ROC分析SUV_(max)、SUV_(mean)判断病灶与正常骨的价值。[结果]两性间正常椎骨SUV_(max)、SU-V_(mean)差异均无统计学意义(P>0.05)。正常椎骨SUV_(mean)与年龄呈显著负相关(P<0.05);SUV_(max)和SUV_(mean)与BMI呈显著正相关(P<0.05)。脊柱骨转移病灶的SUV_(max)、SUV_(mean)显著高于正常椎体(P<0.05)。不同原发肿瘤间SUV_(max)、SUV_(mean)差异均无统计学意义(P>0.05)。边缘清晰与不清晰脊柱骨转移瘤病灶间SUV_(max)、SUV_(mean)差异均无统计学意义(P>0.05)。ROC分析显示SUV_(max)、SUV_(mean)的AUC分别为0.983(95%CI:0.966~1.000)和0.965(95%CI:0.928~1.000)灵敏度分别为92.6%和96.3%,特异度分别为96.3%和88.9%;SUV_(max)和SUV_(mean)对脊柱骨转移瘤最佳诊断阈值分别为11.5、5.7。[结论]正常椎体骨SUV与BMI呈显著正相关,SPECT/CT骨定量SUV分析对诊断脊柱骨转移瘤有一定临床价值。[Objective]To explore the value of bone standardized uptake value(SUV)of SPECT/CT for spinal metastases.[Methods]The ^(99m)Tc-MDP SPECT/CT bone imaging data of 54 patients who were diagnosed of bone metastasis in our hospital from July 2020 to December 2021 were retrospectively analyzed.The SUV were compared between the two genders in normal vertebrae,while the correlation between normal vertebral SUV and body parameters was analyzed.In addition,the SUVs were compared between the normal bone and lesions,among different primary tumor lesions,and between lesions with clear and unclear edges.Furthermore,receiver operator characteristic curve analysis was conducted to search the value of SUV_(max)and SUV_(mean)for differentiate lesion and normal bone.[Results]There were no significant differences in SUV_(max)and SUV_(mean)of normal vertebrae between two genders(P>0.05).However,the SUV_(mean)of normal vertebrae was negatively correlated with age(P<0.05),while the SUV_(max)and SUV_(mean)were positively correlated with BMI(P<0.05).The SUV_(max)and SUV_(mean)in the vertebral metastases lesion were significantly higher than those in the normal vertebral bodies(P<0.05),nevertheless,there were no significant differences in SUV_(max)and SUV_(mean)among different primary tumors(P>0.05).There were no significant differences in SUV_(max)and SUV_(mean)between the lesion with clear edge and that with unclear edge(P>0.05).As results of ROC analysis,the SUV_(max)and SUV_(mean)had area under cure(AUC)of 0.983(95%CI:0.966~1.000)and 0.965(95%CI:0.928~1.000),sensitivity of 92.6%and 96.3%,and specificity of 96.3%和88.9%,respectively.The optimal diagnostic thresholds of SUV_(max)and SUV_(mean)were 11.5 and 5.7,respectively.[Conclusion]There is a significant positive correlation between normal vertebral bone SUV and BMI.SPECT/CT quantitative bone SUV analysis has certain clinical value in the diagnosis of spinal bone metastases.

关 键 词：SPECT/CT 锝-亚甲基二磷酸盐(^(99m)Tc-MDP) 标准化摄取值(SUV) 脊柱骨转移瘤 

分 类 号：R738.1[医药卫生—肿瘤]