载皂苷提取物微球的制备及释药性、抗氧化性研究  

Study on Preparation,Drug Release and Antioxidant Activity of Saponin Extract-loaded Microspheres

作　　者：蔡杰慧 杨英全 黄金燕 CAI Jie-hui;YANG Ying-quan;HUANG Jin-yan(College of Chemisty and Biological Engineering,Guangxi Minzu Normal University,Chongzuo 532200,China;Chongzuo Branch,Southern Manganese Industry Group Co.,Ltd.,Chongzuo 532200,China)

机构地区：[1]广西民族师范学院化学与生物工程学院,广西崇左532200 [2]南方锰业集团有限责任公司崇左分公司,广西崇左532200

出　　处：《化工管理》2023年第10期162-165,共4页Chemical Engineering Management

基　　金：广西高校中青年教师基础能力提升项目(2021KY0773,2022KY0768,2022KY0769)资助;广西民族师范学院科研资助项目(2020YB011,2021YB036,2021YB038);广西壮族自治区一流本科专业建设点制药工程资助(3950010507)。

摘　　要：采用金属离子交联法联合静电作用法制备了载皂苷提取物海藻酸钙-壳聚糖盐酸盐微球,研究其释药性和抗氧化性。利用FTIR和SEM对其进行表征。FT-IR结果表明皂苷提取物载入微球中;SEM结果表明载药微球类球形,表面粗糙;体外释药实验结果表明微球对皂苷提取物具有缓释作用,微球释药机制以骨架溶蚀为主,扩散释药为辅;载药微球对DPPH·和·OH具有较好的清除作用,且清除作用随样品浓度增加而增强。The saponin extract-loaded calcium alginate-chitosan hydrochloride microspheres were prepared by metal ion crosslinking combining with electrostatic method.The drug release and antioxidant activity of microspheres were studied.The microspheres were characterized by FT-IR and SEM.FT-IR results showed that the saponin extract was loaded into the microspheres.SEM results showed that the drug-loaded microspheres were spherical,indicating rough.The results of in-vitro drug release experiments showed that the microspheres had a sustained release effect on the saponin extract.The drug release mechanism of the microspheres was mainly based on the swelling and dissolution of the skeleton,supplemented by diffusion release.The drug-loaded microspheres had a certain effect on DPPH·and·OH,and the scavenging effect increased with the increase of sample concentration.

关 键 词：皂苷提取物 微球 释药性 抗氧化性 

分 类 号：O631[理学—高分子化学]