骨钙素与认知功能及其在运动改善认知功能中的作用机制  

The role of osteocalcin in cognitive function and its promotion by exercise

作　　者：李庆 卜淑敏[1] LI Qing;BO Shumin(Capital University of Physical Education And Sports,Beijing 100191,China)

机构地区：[1]首都体育学院,北京100191

出　　处：《中国骨质疏松杂志》2023年第3期447-451,457,共6页Chinese Journal of Osteoporosis

基　　金：北京市教委科技面上项目(KM201810029003)。

摘　　要：骨钙素是由成骨细胞合成分泌的一种多肽激素,与骨形成密切相关,临床上常用作骨形成标志物。但新近研究发现骨钙素可通过其代谢活跃形式即未羧化骨钙素调节许多生理活动和发育过程,包括对大脑发育、神经结构和认知功能的调节作用。已知未羧化骨钙素可穿过血脑屏障聚集于脑干、丘脑和下丘脑,与中缝背侧核和中缝核中的血清素能神经元特异性结合后,可促进血清素合成、诱导钙流、刺激动作电位频率等。此外,运动可以通过骨钙素改善认知功能并参与痴呆症的预防,但不同类型的运动模式可能会引起不同形式的骨钙素发生变化。本文综述了骨钙素对认知功能的调节以及骨钙素在运动改善认知功能中的作用和机制的研究进展,旨在为探究骨脑的相互作用提供理论参考。Osteocalcin(OC)is a type of multiple peptide hormone formed and secreted by osteoblasts,which is closely related to bone formation and is clinically used as a marker of bone formation.Recently,it has been found that OC regulates many philological and developmental activities,including brain development,nervous construction,and cognitive function,through its active form,non-carboxylated form.It is known that non-carboxylated OC may penetrate blood-brain barrier and concentrated in the brainstem,thalamus,and hypothalamus.After specific binding with serotoninergic neuron in the post raphe nuclei and raphe nuclei,OC stimulates seronine formation,calcium flow,and frequency of action potential.Meanwhile,exercise improves cognitive function and is involved in the prevention of dementia through OC.Different type of exercise may cause different change of OC.In this review,we summarize the advances in the effect and regulation of OC on cognitive function,aiming to provide a basis for further exploration of exercise in promotion of brain health.

关 键 词：骨钙素 认知功能 运动 

分 类 号：R741.02[医药卫生—神经病学与精神病学]