甲状旁腺素调控骨重建过程中成骨分化的研究  

Research on the parathyroid hormone in regulating osteogenic differentiation during bone remodeling

作　　者：张妍 温国琛 侯甜 秦雅芝 谢善恩 董伟 ZHANG Yan;WEN Guochen;HOU Tian;QIN Yazhi;XIE Shanen;DONG Wei(School of Stomatology,North China University of Science and Technology,Tangshan 063210,China)

机构地区：[1]华北理工大学口腔医学院,河北唐山063210

出　　处：《中国骨质疏松杂志》2023年第3期458-463,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(81600844);河北省高等学校科学技术研究项目(QN2020438);河北省卫计委重点科技研究计划(20180745)。

摘　　要：骨改建是维持骨稳态的重要生理过程,包括骨形成和骨吸收。甲状旁腺素在骨改建中发挥重要作用,可以通过多种途径促进骨形成,其研究成果可为促进成骨分化、促进骨折愈合、治疗骨质疏松症等提供新的靶点。本文就甲状旁腺素调控成骨细胞谱系细胞、间充质干细胞等多种细胞的成骨分化研究进展做一综述。Bone remodeling,including bone formation and resorption,is an important physiological process to maintain bone homeostasis.Parathyroid hormone plays a crucial role in bone remodeling.It promotes bone formation through various routes.The findings may lead to novel targets for enhancing osteogenic differentiation,fracture healing,and osteoporosis treatment.This paper mainly reviews the mechanism of parathyroid hormone in the osteogenic differentiation of various cells,including osteoblast lineage cells and mesenchymal stem cells.

关 键 词：甲状旁腺素 成骨细胞 间充质干细胞 成骨分化 骨改建 

分 类 号：R363[医药卫生—病理学] R969[医药卫生—基础医学]