Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations  

作　　者：Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera 

机构地区：[1]Intensive Care Unit,Hospital Universitario de Canarias,La Laguna 38320,Spain [2]Intensive Care Unit,Hospital Universitario Nuestra Señora Candelaria,Santa Cruz Tenerife 38010,Spain [3]Department of Surgery,Hospital Universitario Nuestra Señora de Candelaria,Santa Cruz Tenerife 38010,Spain [4]Department of Laboratory,Hospital Universitario de Canarias,La Laguna 38320,Spain [5]Department of Digestive,Hospital Universitario Nuestra Señora de Candelaria,Santa Cruz Tenerife 38010,Spain [6]Research Unit,Hospital Universitario de Canarias,La Laguna 38320,Spain [7]Transplant Unit,Hospital Universitario Nuestra Señora Candelaria,Santa Cruz Tenerife 38010,Spain [8]Department of Radiology,Hospital Universitario Nuestra Señora Candelaria,Santa Cruz Tenerife 38010,Spain

出　　处：《World Journal of Clinical Cases》2023年第8期1753-1760,共8页世界临床病例杂志

摘　　要：BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis pathway.High expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was small.AIM To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample size.METHODS Patients underwent LT due to HCC were included in this retrospective study.Serum sFasL levels prior to LT were measured and one-year LT mortality was registered.RESULTS Non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;P<0.001]than surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;P=0.001)independently of age of LT donor in the logistic regression analysis.CONCLUSION We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.

关 键 词：SFASL Hepatocellular carcinoma Liver transplantation MORTALITY OUTCOME 

分 类 号：R735.7[医药卫生—肿瘤]