Risk factors predict microscopic extranodal tumor deposits in advanced stage Ⅲ colon cancer patients  

作　　者：Yi-Han Jhuang Yu-Ching Chou Yu-Chun Lin Je-Ming Hu Ta-Wei Pu Chao-Yang Chen 

机构地区：[1]Division of Cardiovascular Surgery,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan,China [2]School of Public Health,National Defense Medical Center,Taipei 114,Taiwan,China [3]Department of Pathology,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan,China [4]Division of Colorectal Surgery,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan,China [5]Division of Colorectal Surgery,Tri-Service General Hospital Song-shan Branch,National Defense Medical Center,Taipei 114,Taiwan,China

出　　处：《World Journal of Gastroenterology》2023年第11期1735-1744,共10页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant metastases.Pericolonic tumor deposits(TDs)are considered prognostically distinct from lymph node metastases.AIM To investigate risk factors for extranodal TDs in stage III colon cancer.METHODS This was a retrospective cohort study.We selected 155 individuals diagnosed with stage III colon cancer from the database of the Cancer Registry of the Tri-Service General Hospital.The patients were allocated into the groups with/without N1c.Multivariate Cox regression analysis and Kaplan-Meier method were done.The primary outcomes investigate the association between the covariates and extranodal TDs,and prognostic significance of the covariates regarding the survival.RESULTS There were 136 individuals in the non-N1c group and 19 individuals in the N1c group.Patients with lymphovascular invasion(LVI)had a higher risk of TDs.Overall survival rates of patients with and without LVI were 6.64 years and 8.61 years,respectively(P=0.027).The N1c patients without LVI had higher overall survival than those who with LVI(7.73 years vs 4.42 years,P=0.010).CONCLUSION Patients having stage III colon cancer with LVI have a higher probability of having TDs than those with stage III colon cancer without LVI.Stage III colon cancer patients with TDs and LVI could have poor prognosis and outcome.

关 键 词：Colon cancer Tumor deposits Lymphovascular invasion Risk factor 

分 类 号：R735.35[医药卫生—肿瘤]