口腔白斑病自体荧光成像结果与临床病理特征相关性分析  

Correlation analysis between autofluorescence imaging results and clinicopathological characteristics of oral leukoplakia

作　　者：李晨曦[1] 施芷怡 喻仲麟 周曾同[1] 施琳俊[1] LI Chen-xi;SHI Zhi-yi;YU Zhong-lin;ZHOU Zeng-tong;SHI Lin-jun(Department of Oral Mucosal Diseases,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laborato-ry of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔黏膜病科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011

出　　处：《临床口腔医学杂志》2023年第3期153-157,共5页Journal of Clinical Stomatology

基　　金：国家自然科学基金项目(82170952);上海市卫生健康委员会卫生行业临床研究专项青年项目(20214Y0192)、面上项目(202040457);上海市科委2020年度“科技创新行动计划”医学创新研究专项(20Y11903700);上海市申康医院发展中心第二轮三年行动计划重大临床研究项目(SHDC2020CR4082);上海交通大学医学院高水平地方高校协同创新团队(SHSMU-ZLCX20212401);上海交通大学医学院高峰学科—“研究型医师”;上海交通大学医学院附属第九人民医院研究型学科(KQYJXK2020)。

摘　　要：目的:探究口腔白斑病自体荧光成像结果与患者临床病理特征的相关性。方法:评估199例口腔白斑病患者自体荧光成像结果与临床病理特征之间的相关性。单因素Logistic回归分析自体荧光成像结果在不同临床病理特征间的差异,由此得到风险因素,进一步使用多因素Logistic回归分析显著因素。结果:199例研究对象中,129例表现为自体荧光缺失。单因素Logistic回归分析提示清淡饮食习惯(P=0.010)、舌缘舌腹部位(P=0.001)、非均质型损害(P<0.001)和高风险上皮异常增生程度(P<0.001)的口腔白斑病患者发生自体荧光缺失的风险高于对照组,是自体荧光缺失的风险因素。多因素Logistic回归提示舌缘舌腹损害(OR=2.48,P=0.014)、非均质型损害(OR=4.97,P=0.002)及高风险上皮异常增生程度(OR=2.45,P=0.034)是自体荧光缺失的独立风险因素。结论:舌侧舌腹损害、非均质型损害及高风险上皮异常增生的口腔白斑病患者发生自体荧光缺失的风险更高。这些特征提示临床医生应进行更密切的临床随访和早期治疗干预。Objective:To investigate the correlation between autofluorescence imaging result and clinicopathological characteristics of oral leukoplakia(OL)patients.Methods:To evaluate the correlation between autofluorescence imaging findings and clinicopathological characteristics in 199 patients with oral leukoplakia.Univariate logistic regression was used to analyze the differences of autofluorescence imaging result among different clinicopathological characteristics,from which risk factors were obtained,and then multivariate logistic regression analysis was used to further analyze significant factors.Results:Of the 199 subjects studied,129 showed loss of autofluorescence(LAF).Univariate logistic regression showed the risk of LAF was higher in OL patients with bland diet(P=0.010),lateral/ventral tongue lesions(P=0.001),non-homogenous lesions(P<0.001)and high-risk epithelial dysplasia(P<0.001).Multivariate logistic regression indicated that lateral/ventral tongue lesions(OR=2.48,P=0.014),non-homogenous lesions(OR=4.97,P=0.002)and high-risk epithelial dysplasia(OR=2.45,P=0.034)were independent risk factors of LAF.Conclusion:The risk of LAF were higher in oral leukoplakia patients with lateral/ventral tongue location,non-homogenous type,and high-risk epithelial dysplasia.These characteristics reminded clinicians high frequency follow-up and early therapeutic intervention.

关 键 词：自体荧光检查 口腔白斑病 临床病理特征 相关性分析 

分 类 号：R781.[医药卫生—口腔医学]