2014年至2017年双相障碍患者药品处方情况调查  

Retrospective analysis of drug prescriptions for patients with bipolar disorder from 2014 to 2017

作　　者：王威[1,2] 周佳[1,2] 任艳萍[1,2] 张杰英 李胜[1,2] 徐劲节 WANG Wei;ZHOU Jia;REN Yan-ping;ZHANG Jie-ying;LI Sheng;XU Jin-jie(Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders&National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神疾病医学中心,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,100088 [2]人脑保护高精尖创新中心,首都医科大学,100088

出　　处：《临床精神医学杂志》2023年第2期89-93,共5页Journal of Clinical Psychiatry

基　　金：国家重点研发计划(2017YFC1311101);北京市属医院科研培育计划项目(PX2021070);北京安定医院院科研基金(YJ2022-06)。

摘　　要：目的:了解2014年至2017年双相障碍住院患者的药品处方情况和用药方案变化趋势。方法:利用电子病历系统,回顾性分析2014年至2017年在首都医科大学附属北京安定医院住院的双相障碍患者心境稳定剂、抗精神病药和抗抑郁药的处方情况,比较不同年份用药方案的差异。结果:共纳入8148例患者。在药品处方方面,心境稳定剂占比最高,其中丙戊酸盐呈波动上升趋势(P<0.01);抗精神病药占比次之,其中喹硫平和阿立哌唑呈上升趋势,奥氮平呈下降趋势(P<0.05或P<0.01);抗抑郁药占比一直波动在低位。在用药方案方面,联合用药占主导,其中心境稳定剂联合抗精神病药占比最高(73.3%),不同年份间差异无统计学意义。结论:我院双相障碍住院患者以联合使用心境稳定剂和抗精神病药为主,其中丙戊酸盐、喹硫平和阿立哌唑的使用呈上升趋势。Objective:To investigate the changes of prescriptions of psychotropics and medication regimen in hospitalized patients with bipolar disorder from 2014 to 2017.Method:Using the electronic medical record system,the prescriptions of mood stabilizers,antipsychotics and antidepressants in patients with bipolar disorder hospitalized in Beijing Anding Hospital Affiliated to Capital Medical University from 2014 to 2017 were retrospectively analyzed,and the differences of medication schemes in different years were compared.Results:A total of 8148 patients were included.Among the prescriptions of psychotropic drugs,mood stabilizers accounted for the highest proportion,among which valproate showed a fluctuating upward trend(P<0.01).Antipsychotics took the second place,in which quetiapine and aripiprazole showed an upward trend,olanzapine showed a downward trend(P<0.05 or P<0.01).The proportion of antidepressants fluctuated at a low level.In terms of treatment scheme,combined medication was dominant,among which mood stabilizer combined with antipsychotics accounted for the highest proportion(73.3%),and there was no significant difference among different years.Conclusion:The use of combined mood stabilizers and antipsychotics was predominant in our bipolar disorder inpatients,with a rising trend in the use of valproate,quetiapine and aripiprazole.

关 键 词：双相障碍 用药方案 趋势 

分 类 号：R749.4[医药卫生—神经病学与精神病学]