脑源性神经营养因子基因甲基化在抑郁症发病机制中作用研究进展  

Advances in the role of brain-derived neurotrophic factor gene methylation in the pathogenesis of depression

作　　者：刘瑞梅 张晨[1] LIU Rui-mei;ZHANG Chen(Biochemical laboratory,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心生化研究室,200030

出　　处：《临床精神医学杂志》2023年第2期151-153,共3页Journal of Clinical Psychiatry

基　　金：国家重点研发计划(2018YFC1314300);国家自然科学基金(81771450,81471358)。

摘　　要：抑郁症是一种常见的情绪障碍,发病机制涉及遗传、环境、神经生化和神经内分泌等方面。某些环境因素可通过表观遗传机制发挥作用,成为抑郁症认知和行为异常的基础;其中研究较为广泛的是脑源性神经营养因子(BDNF)基因。本综述主要对BDNF基因甲基化与抑郁症的相关性进行综述。Depression is a common mood disorder,the pathogenesis involves genetics,environment,neural biochemistry and neuroendocrinology.Some environmental factors play a role through epigenetic mechanism and cause the abnormalities of cognition and behavior in depression.The brain-derived neurotrophic factor(BDNF)gene has been extensively studied.This review mainly demonstrates the correlation between the methylation of BDNF gene and the etiology of depression.

关 键 词：抑郁症 表观遗传 脑源性神经营养因子基因 甲基化 

分 类 号：R749.4[医药卫生—神经病学与精神病学]