重复经颅磁刺激改善精神分裂症工作记忆缺陷的研究进展  

Effects of repetitive transcranial magnetic stimulation on working memory deficits in schizophrenia:a review

作　　者：侯文鹏 李先宾 王传跃[1,2] HOU Wen-peng;LI Xian-bin;WANG Chuan-yue(The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders&Beijing Institute for Brain Disorders Center of Schizophrenia,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京脑重大疾病研究院精神分裂症研究所,100088 [2]人脑保护高精尖创新中心,首都医科大学,100088

出　　处：《临床精神医学杂志》2023年第2期154-156,共3页Journal of Clinical Psychiatry

基　　金：国家科技重大专项重大新药创制(2018ZX09201-014);国家自然科学基金项目(81971250,81971287);北京市“扬帆”临床技术创新项目(XMLX201849);北京市首都卫生发展科研专项(2018-2-2123)。

摘　　要：工作记忆缺陷是精神分裂症神经认知障碍的一个主要方面,有研究显示重复经颅磁刺激(rTMS)可明显改善精神分裂症患者的工作记忆缺陷,但不同研究的结果缺乏一致性。本文拟介绍精神分裂症的工作记忆缺陷及其相关重要脑区,综述rTMS治疗精神分裂症工作记忆缺陷的临床试验新进展,并提出下一步的研究方向。Working memory deficits are a major aspect of neurocognitive impairment in schizophrenia.Studies have shown that repetitive transcranial magnetic stimulation(rTMS)can significantly improve working memory deficits in schizophrenia,but the results from different studies are inconsistent.In this paper,working memory deficits and their related important brain regions in schizophrenia are introduced,and the new progress of clinical trials on the treatment of working memory deficits in schizophrenia by rTMS is reviewed.

关 键 词：精神分裂症 重复经颅磁刺激 工作记忆 

分 类 号：R749.3[医药卫生—神经病学与精神病学]