PD-1/PD-L1通路与多发性硬化关系的研究进展  

Recent advance in relations of programmed cell death-1/programmed cell death-ligands-1 pathway with multiple sclerosis

作　　者：孟祥斐 孟祥慧 孙温伟 Meng Xiangfei;Meng Xianghui;Sun Wenwei(Department of Neurology,Linyi Traditional Chinese Medical Hospital,Linyi 276003,China;Department of Internal Medicine,Linyi Traditional Chinese Medical Hospital,Linyi 276003,China;Department of General Medicine,Weifang People's Hospital,Weifang 261041,China)

机构地区：[1]临沂市中医医院脑病科,临沂276003 [2]临沂市中医医院内科,临沂276003 [3]潍坊市人民医院全科医学科,潍坊261041

出　　处：《中华神经医学杂志》2023年第3期311-317,共7页Chinese Journal of Neuromedicine

摘　　要：多发性硬化(MS)是一种以中枢神经系统脱髓鞘、轴索损伤和神经元丢失为特征的自身免疫性疾病。实验性自身免疫性脑脊髓炎(EAE)是研究MS的经典动物模型。目前,越来越多的研究表明程序性死亡受体-1(PD-1)/程序性死亡配体-1(PD-L1)通路参与了多种自身免疫性疾病的发病机制。笔者现全面总结近年来关于PD-1/PD-L1通路在MS及其动物模型EAE发病机制中的研究进展,并探讨该通路作为MS治疗新靶点的潜力,以期为MS的免疫治疗研究提供参考。Multiple sclerosis(MS)is an autoimmune disease characterized by demyelination,axonailnjury,and neuronal loss in central nervous system.Experimental autoimmune encephalomyelitis(EAE)animal model is widely used in MS.Accumulating evidences indicate that the programmed cell death-1/programmed cell death-ligands-1(PD-1/PD-L1)pathway participates in pathogenesis of autoimmune diseases.The authors comprehensively review the roles of PD-1/PD-L1 pathway in pathogenesis of MS and EAE animal model,and discuss the potential of this pathway as a new therapeutic target for MS,to provide reference for immunotherapy research of MS.

关 键 词：多发性硬化 实验性自身免疫性脑脊髓炎 程序性死亡受体-1 程序性死亡配体-1 淋巴细胞 

分 类 号：R744.51[医药卫生—神经病学与精神病学]