CRABP2、FABP5、RARγ和PPARβ/δ在食管鳞癌中的表达及临床意义  

Expression and clinical significance of CRABP2,FABP5,RARγand PPARβ/δin esophageal squamous cell carcinoma tissues

作　　者：李梦妍[1,2] 侯国胜 高永梅 戴利涛 王波 马遇庆 LI Mengyan;HOU Guosheng;GAO Yongmei;DAI Litao;WANG Bo;MA Yuqing(Department of Pathology,First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Urumqi 830011,China;Department of Pathology,Changji Jewel Flower Hospital,Xinjiang Fukang 831511,China;Department of Pathology,Urumqi Friendship Hospital,Xinjiang Urumqi 830002,China.;Department of Surgery,Changji Jewel Flower Hospital,Xinjiang Fukang 831511,China)

机构地区：[1]省部共建中亚高发病成因与防治国家重点实验室,新疆医科大学第一附属医院病理科,新疆乌鲁木齐830011 [2]昌吉州宝石花医院病理科,新疆阜康831511 [3]乌鲁木齐市友谊医院病理科,新疆乌鲁木齐830002 [4]昌吉州宝石花医院外科,新疆阜康831511

出　　处：《现代肿瘤医学》2023年第8期1448-1455,共8页Journal of Modern Oncology

基　　金：新疆维吾尔自治区省部共建中亚高发病成因与防治国家重点实验室面上项目(编号:SKL-HIDCA-2021-27,SKL-HIDCA-2022-10);新疆维吾尔自治区自然科学基金面上项目(编号:2021D01A12)。

摘　　要：目的:探讨CRABP2、FABP5、RARγ和PPARβ/δ在食管鳞状细胞癌中的表达及临床意义。方法:应用免疫组织化学染色法检测172例食管鳞癌患者和配对的癌旁正常组织中CRABP2、FABP5、RARγ、PPARβ/δ的表达,统计学方法分析各蛋白的表达与临床病理特征的关系并评估预后价值。结果:CRABP2和FABP5在食管鳞癌中低表达,CRABP2的低表达和ESCC临床病理特征无相关性;FABP5的高表达与淋巴结转移(P=0.032)、浸润深度(P=0.041)、AJCC分期(P=0.013)相关。CRABP2和FABP5之间呈正相关(r=0.156,P=0.041)。CRABP2高表达患者的总生存期较长(P=0.025),CRABP2可以作为评估食管鳞癌患者总生存期的独立预后因素,FABP5则是评估食管鳞癌患者无进展生存期的独立预后因素。结论:CRABP2和FABP5有望成为改善食管鳞癌预后的新靶点。Objective:To investigate at the expression and clinical significance of CRABP2,FABP5,RARγ,and PPARβ/δin esophageal squamous cell carcinoma(ESCC).Methods:In 172 ESCC patients and paired normal tissues,CRABP2,FABP5,RARγ,and PPARβ/δexpression were identified employing immunohistochemical staining.Statistical methods were used to analyze the relation between proteins expression,clinical pathological characteristics and assess prognostic value.Results:There was no link between low expression of CRABP2 and ESCC clinicopathological characteristics.High expression of FABP5 was related with lymph node metastases(P=0.032),depth of infiltration(P=0.041),AJCC staging(P=0.013).The expression of CRABP2 was positively correlated with the expression of FABP5(r=0.156,P=0.041).The overall survival of patients with high expression of CRABP2 was longer(P=0.025),CRABP2 could be used as an independent prognostic factor for assessing OS in patients with ESCC.FABP5 is an independent prognostic factor used to assess PFS in ESCC patients.Conclusion:CRABP2 and FABP5 might be new therapeutic targets for ESCC.

关 键 词：食管鳞状细胞癌 CRABP2 FABP5 预后 

分 类 号：R735.1[医药卫生—肿瘤]