Recent advances in surface endothelialization of the magnesium alloy stent materials  

作　　者：Changjiang Pan Xuhui Liu Qingxiang Hong Jie Chen Yuxin Cheng Qiuyang Zhang Lingjie Meng Juan Dai Zhongmei Yang Lingren Wang 

机构地区：[1]Faculty of Mechanical and Material Engineering,Jiangsu Provincial Engineering Research Center for Biomaterials and Advanced Medical Devices,Huaiyin Institute of Technology,Huai’an 223003,China [2]The Affiliated Huai’an Hospital of Xuzhou Medical University,Huai’an 223003,China

出　　处：《Journal of Magnesium and Alloys》2023年第1期48-77,共30页镁合金学报（英文）

基　　金：financially supported by the National Natural Science Foundation of China(31870952);Natural Science Foundation of Jiangsu Province of China(BK20181480)。

摘　　要：Magnesium and its alloy have good mechanical properties and biodegradability,and have become the hotspot of the next-generation biodegradable vascular stent materials.However,their rapid degradation in vivo and poor biocompatibility are still the bottlenecks of clinical applications for the cardiovascular stents.In particular,how to induce the repair and regeneration of the vascular endothelial with normal physiological functions on the surface of the magnesium alloy stent materials represents the key to its clinical application in the field of cardiovascular stents.It has been believed that it is an ideal way to completely solve the postoperative complications through constructing the multifunctional anti-corrosive bioactive coating on the magnesium alloy surface to induce the formation of vascular endothelium with normal physiological functions.However,how to construct a corrosion-resistant multifunctional bioactive coating with the good endothelial regeneration abilities on the magnesium alloy surface still faces a great challenge.This paper mainly focused on highlighting and summarizing the recent advances in the surface endothelialization of the magnesium alloy materials for the vascular stent,including the bio-inert coating,in-situ immobilization of bioactive molecules on the surface,polymer coating loaded with bioactive factors,novel multifunctional polymer coating,bioactive micropatterns,bioactive layer with glycocalyx-like structure,NO-releasing coating and bioactive sol-gel coating.The advantages and disadvantages of these strategies were discussed and analyzed.Finally,in the senses of future development and clinical application,this paper analyzed and summarized the development direction and prospect of surface endothelialization of the magnesium alloy vascular stents.It is anticipated that this review can give the new cues to the surface endothelialization of the cardiovascular magnesium alloy stents and promote future advancements in this field.

关 键 词：Magnesium alloy STENT ENDOTHELIALIZATION Surface coating Surface modification 

分 类 号：TG146[一般工业技术—材料科学与工程]