苦黄注射液与亮菌甲素治疗急性黄疸性肝炎患者的效果对比  

Comparison of Effect of Kuhuang Injection and Armillarisin A in the Treatment of Acute Icteric Hepatitis

作　　者：吴迪 陶云平[2] 邱榕[2] WU Di;TAO Yunping;QIU Rong(Zhenjiang Third People's Hospital,Zhenjiang 212000,China;不详)

机构地区：[1]镇江市第三人民医院,江苏镇江212000 [2]江苏大学附属医院

出　　处：《中外医学研究》2023年第8期133-136,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:对比苦黄注射液与亮菌甲素治疗急性黄疸性肝炎患者的效果。方法:选取2019年1月—2022年1月镇江市第三人民医院收治的102例急性黄疸性肝炎患者作为研究对象,采用随机数表法分为研究组(亮菌甲素,51例)和对照组(苦黄注射液,51例)。比较两组治疗前后肝功能指标[天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血清总胆红素]、血常规[白细胞(WBC)、血小板(PLT)]、血清学肝损伤指标[白细胞介素-18(IL-18)、一氧化氮(NO)]及治疗期间不良反应(乏力、干呕、恶心、呕吐)发生情况。结果:治疗前,两组肝功能指标、血清学肝损伤指标比较,差异均无统计学意义(P>0.05);治疗后,两组AST、ALT、总胆红素、NO、IL-18较治疗前均降低,且研究组均低于对照组,差异均有统计学意义(P<0.05)。两组治疗前后WBC、PLT比较,差异均无统计学意义(P>0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(χ^(2)=3.991,P=0.046)。结论:与苦黄注射液相比,亮菌甲素治疗急性黄疸性肝炎患者可有效改善肝功能及血清学肝损伤指标,降低不良反应发生率。Objective:To compare the efficacy of Kuhuang Injection and Armillarisin A in the treatment of acute icteric hepatitis.Method:A total of 102 patients with acute icteric hepatitis who admitted to Zhenjiang Third People's Hospital from January 2019 to January 2022 were selected as research objects,and they were divided into the study group(Armillarisin A,51 cases)and the control group(Kuhuang Injection,51 cases)by random number table method.The liver function indexes[aspartate aminotransferase(AST),alanine aminotransferase(ALT)and serum total bilirubin],blood routine[white blood cells(WBC),platelets(PLT)],serological liver injury indexes[interleukin-18(IL-18),nitric oxide(NO)]before and after treatment,adverse reactions(fatigue,dryness,nausea,vomiting)during treatment were compared between two groups.Result:Before treatment,there were no significant differences in liver function indexes and serological liver injury indexes between two groups(P>0.05);after treatment,the levels of AST,ALT,total bilirubin,NO and IL-18 in two groups were lower than those before treatment,and the study group were lower than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in WBC,PLT before and after treatment between two groups(P>0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(x^(2)=3.991,P=0.046).Conclusion:Compared with Kuhuang Injection,Armillarisin A in the treatment of patients with acute icteric hepatitis can effectively improve liver function and serological liver injury indicators,and reduce adverse reactions.

关 键 词：急性黄疸性肝炎 亮菌甲素 白细胞介素-18 一氧化氮 肝损伤指标 

分 类 号：R575.1[医药卫生—消化系统]