奥曲肽联合奥美拉唑治疗消化性溃疡合并上消化道出血的效果  

Effect of Octreotide Combined with Omeprazole in the Treatment of Peptic Ulcer Complicated with Upper Gastrointestinal Bleeding

作　　者：孙育新[1] 房太勇[1] SUN Yuxin;FANG Taiyong(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学附属第二医院,福建泉州362000

出　　处：《中外医学研究》2023年第9期52-55,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究奥曲肽联合奥美拉唑治疗消化性溃疡合并上消化道出血的效果。方法:以2020年1月—2022年2月福建医科大学附属第二医院收治的152例消化性溃疡合并上消化道出血患者为研究对象,采用随机数表法分为两组,对照组采用奥美拉唑治疗,治疗组采用奥曲肽联合奥美拉唑治疗。比较两组临床疗效、临床指标、凝血-纤溶系统指标、炎症因子、胃蛋白酶原及不良反应发生率。结果:治疗组总有效率为96.05%(73/76),高于对照组的85.53%(65/76),差异有统计学意义(P<0.05);治疗组平均止血时间、潜血转阴时间、住院时间均短于对照组,输血量少于对照组,差异均有统计学意义(P<0.05);治疗14 d后,两组凝血-纤溶系统指标、炎症因子与胃蛋白酶原水平较治疗前均改善,且治疗组活化部分凝血酶(APTT)、凝血酶(TT)、凝血酶原(PT)及血清白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平均低于对照组,血浆纤维蛋白原(FIB)高于对照组,差异均有统计学意义(P<0.05);治疗组不良反应发生率为10.53%(8/76),与对照组的6.58%(5/76)比较,差异无统计学意义(P>0.05)。结论:奥曲肽联合奥美拉唑治疗消化性溃疡合并上消化道出血患者可进一步提升效果,缓解临床症状,调节凝血功能水平,促进病情恢复。Objective:To study the effect of Octreotide combined with Omeprazole in the treatment of peptic ulcer complicated with upper gastrointestinal bleeding.Method:A total of 152 patients with peptic ulcer complicated with upper gastrointestinal bleeding who admitted to the Second Affiliated Hospital of Fujian Medical University from January 2020 to February 2022 were selected and divided into two groups by the number table method.The control group was treated with Omeprazole,and the treatment group was treated with Octreotide combined with Omeprazole.The clinical efficacy,clinical observation indexes,coagulation and fibrinolytic system indexes,inflammatory factors,prothrombin,incidence of adverse reactions were compared between two groups.Result:The total effective rate of the treatment group was 96.05%(73/76),which was higher than 85.53%(65/76)of the control group,the difference was statistically significant(P<0.05).The average hemostatic time,occult blood negative time and hospital stay of the treatment group were shorter than those of the control group,and the blood transfusion volume was less than that of the control group,the differences were statistically significant(P<0.05).After 14 d of treatment,the coagulation-fibrinolytic system indexes,inflammatory factors and pepsinogen levels in two groups were improved compared with those before treatment,the levels of activated partial thrombin(APTT),thrombin(TT),prothrombin(PT),serum interleukin-6(IL-6),interleukin-17(IL-17),pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)in the treatment group were lower than those in the control group,while the level of plasma fibrinogen(FIB)in the treatment group was higher than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was 10.53%(8/76),compared with 6.58%(5/76)in the control group,and the difference was not statistically significant(P>0.05).Conclusion:Octreotide combined with Omeprazole in the treatment of peptic ulcer patients complicated

关 键 词：奥曲肽 奥美拉唑 消化性溃疡 上消化道出血 凝血-纤溶系统 

分 类 号：R573.1[医药卫生—消化系统] R573.2[医药卫生—内科学]