Fighting age-related orthopedic diseases: focusing on ferroptosis  

作　　者：Qin Ru Yusheng Li Wenqing Xie Yilan Ding Lin Chen Guodong Xu Yuxiang Wu Fudi Wang 

机构地区：[1]Department of Health and Physical Education,Jianghan University,Wuhan,430056,China [2]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,410008,China [3]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,410008,China [4]The Second Affiliated Hospital,School of Public Health,State Key Laboratory of Experimental Hematology,Zhejiang University School of Medicine,Hangzhou,China [5]The First Affiliated Hospital,Basic Medical Sciences,School of Public Health,Hengyang Medical School,University of South China,Hengyang,China

出　　处：《Bone Research》2023年第1期1-20,共20页骨研究（英文版）

基　　金：National Natural Science Foundation of China (82071970,81874030, 82072506, 92268115, and 31930057);National Key R&D Program of China(2019YFA0111900 and 2018YFA0507802);Innovation-Driven Project of Central South University (2020CX045);Key Program of Health Commission of Hunan Province(20201902);Young Talents Project of Hubei Provincial Health Commission(WJ2021Q053);Science and Technology Innovation Program of Hunan Province (No.2021RC3025);Innovation Project for Postgraduate Students of Central South University (2021zzts1024);Science and Technology Innovation Project of Jianghan University (2021kjzx008)。

摘　　要：Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid metabolism, and the biosynthesis of compounds with antioxidant activities, including glutathione. In the past 10 years, increasing evidence has indicated a potentially strong relationship between ferroptosis and the onset and progression of age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Therefore, in-depth knowledge of the regulatory mechanisms of ferroptosis in age-related orthopedic diseases may help improve disease treatment and prevention. This review provides an overview of recent research on ferroptosis and its influences on bone and cartilage homeostasis. It begins with a brief overview of systemic iron metabolism and ferroptosis,particularly the potential mechanisms of ferroptosis. It presents a discussion on the role of ferroptosis in age-related orthopedic diseases, including promotion of bone loss and cartilage degradation and the inhibition of osteogenesis. Finally, it focuses on the future of targeting ferroptosis to treat age-related orthopedic diseases with the intention of inspiring further clinical research and the development of therapeutic strategies.

关 键 词：METABOLISM DISEASES PEROXIDATION 

分 类 号：R68[医药卫生—骨科学]