The role of TGF-beta3 in cartilage development and osteoarthritis  

作　　者：Xinmei Du Linyi Cai Jing Xie Xuedong Zhou 

机构地区：[1]State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,610041,Chengdu,China [2]National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,610041,Chengdu,China

出　　处：《Bone Research》2023年第1期108-123,共16页骨研究（英文版）

基　　金：National Natural Science Foundation of China(81771047 to J.X.,81670978 and 81870754 to X.Z.);Sichuan Science&Technology Innovation Talent Project(2022JDRC0044)。

摘　　要：Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and pathology.TGF-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and differentiation.Since TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage development.Increased TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of disease.Recently,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged cartilage.However,the biological mechanism of TGF-β3 action in cartilage development and OA is not well understood.In this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment.

关 键 词：CARTILAGE protective VERSATILE 

分 类 号：R681.3[医药卫生—骨科学] R684.3[医药卫生—外科学]