β-萘酚α位反应的研究进展  

Recent Advances in the Reactions ofβ-Naphthol atα-Position

作　　者：刘静 陈锦涛 刘婷婷 刘佳 曾要富 Liu Jing;Chen Jintao;Liu Tingting;Liu Jia;Zeng Yaofu(School of Pharmaceutical Science,Hengyang Medical School,University of South China,Hengyang,Hunan 421000)

机构地区：[1]南华大学衡阳医学院药学院,湖南衡阳421000

出　　处：《有机化学》2023年第2期379-410,共32页Chinese Journal of Organic Chemistry

基　　金：湖南省大学生创新创业课题(Nos.S202210555288,S202110555254);南华大学大学生创新创业课题(No.X202210555181)资助项目。

摘　　要：萘酚是有机合成中一种重要的合成子,其α位化学性质活泼,可参与多种化学反应,受到了化学家的广泛关注.β-萘酚的α位可以发生多种化学转化,如烷基化、芳基化、环化、胺化和卤化等,利用这些化学反应可以构建结构多样化且具有不同生物活性的萘酚衍生物.这些萘酚衍生物既可以作为天然活性药物的关键骨架,也可以用于制备化学合成中的重要中间体.基于近年来β-萘酚α位的化学反应层出不穷,主要从β-萘酚α位碳-碳键和碳-杂键(C—N,C—O,C—X,C—S,C—P)的构建来对β-萘酚α位的相关反应进行了综述.β-Naphthol is an important synthon in organic synthesis and can participate in various chemical reactions due to its active chemical property atα-site,which has attracted a great attention from chemists.β-Naphthol can undergo various chemical transformations atα-position,such as alkylation,arylation,cyclization,amination,halogenation and so on,which can be used to construct structurally diverse naphthol derivatives with various biological activities.These naphthol derivatives can be used not only as the privileged skeletons of natural active drugs,but also as the building blocks for the preparation of the important intermediates in chemical synthesis.In recent years,chemical reactions based onβ-naphthol atα-site have emerged one after another.The reactions ofβ-naphthol atα-position are reviewed from the aspects of C—C,C—N,C—O,C—X,C—S,C—P bond constructions and so on.

关 键 词：Β-萘酚 Α位 碳-碳键 碳-杂键 

分 类 号：O621.25[理学—有机化学]