生酮饮食与高级别胶质瘤的研究进展  

Progress on Ketogenic Diet and High-Grade Gliomas

作　　者：刘晓慧 黄爽[2] 陈媛媛[3] LIU Xiao-hui;HUANG Shuang;CHEN Yuan-yuan(The Second Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China;Zhejiang Cancer Hospital,Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou 310022,China;Sun Yatsen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江省肿瘤医院,中国科学院基础医学与肿瘤研究所,浙江杭州310022 [3]中山大学肿瘤防治中心,广东广州510060

出　　处：《肿瘤学杂志》2023年第1期61-65,共5页Journal of Chinese Oncology

基　　金：浙江省卫生健康科技计划项目(2021KY597);东莞市科技特派员项目(20211800500322)。

摘　　要：高级别胶质瘤是一种恶性程度较高的神经胶质瘤,临床上常用的治疗方法以手术为主,术后予放化疗辅助治疗。由于高级别胶质瘤呈浸润性生长,治疗效果欠佳。为了进一步提高治疗效果,许多研究者开始将生酮饮食应用于高级别胶质瘤治疗中。生酮饮食是通过减少肿瘤细胞对葡萄糖的吸收,降低氧化应激水平,增加机体对肿瘤细胞的免疫反应和减轻炎症来实现抗肿瘤的作用,这种作用在一系列细胞、动物实验及临床预试验中得到了证实。在高级别胶质瘤中,生酮饮食也被证实是可行且安全的,但仍存在一些问题需要解决,需要高度选择适应患者人群。High-grade glioma is a kind of glioma with a high degree of malignancy. Surgery and postoperative chemoradiotherapy is the main treatment for high-grade gliomas. However, due to the invasive growth nature, treatment is not always effective. The ketogenic diet is widely adapted for patients along with the treatment of high-grade glioma. Ketogenic diet can achieve adjuvant anti-tumor effect by reducing the tumor absorption of glucose, decreasing oxidative stress level, increasing the immune response and alleviating inflammation, which have been confirmed by large amount of laboratory studies and clinical pre-trials. Ketogenic diet is feasible and safe for highgrade glioma patients, but the adapting population need to be selected and there are still some problems to be solved.

关 键 词：高级别胶质瘤 生酮饮食 能量代谢 

分 类 号：R739.41[医药卫生—肿瘤]