FHL1在恶性肿瘤发生发展中的调控机制研究进展  

Research progress on the regulatory mechanism of FHL1 in the occurrence and development of malignant tumors

作　　者：闫颖 魏祎 盛芸芸 胡天惠[3] YAN Ying;WEI Yi;SHENG Yun-yun;HU Tian-hui(Gannan Medical University,Ganzhou,Jiangxi 341000;Xiamen University;Anti-cancer Research Center of Xiamen University,Xiamen,Fujian 361100)

机构地区：[1]赣南医学院,江西赣州341000 [2]厦门大学 [3]厦门大学抗癌研究中心,福建厦门361100

出　　处：《赣南医学院学报》2023年第2期113-119,共7页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：心脑血管疾病防治教育部重点实验室开放课题(XN201809)。

摘　　要：4个半LIM结构域蛋白1(Four and a half LIM domains protein 1,FHL1)属于LIM-only家族成员之一,通过LIM结构域与其他蛋白相互作用,在转录调节、细胞运动和细胞增殖等功能中发挥重要作用,而且与肺癌、乳腺癌、胃肠道肿瘤、膀胱癌等多种肿瘤的发生发展密切相关。已有研究证实,FHL1在肌肉发育、肌病和心血管疾病中的重要性。本文综述了FHL1在多种肿瘤发生发展中的作用,旨在为临床寻找新型的生物标记物和药物作用靶点提供思路。Four and a half LIM domains protein 1(FHL1),one of the LIM-only family members,plays an important role in transcriptional regulation,cell movement and cell proliferation by interacting with other proteins through LIM domain.It is also closely related to the occurrence and development of various tumors such as lung cancer,breast cancer,gastrointestinal cancer,bladder cancer,etc.Previous studies have confirmed the importance of FHL1 in muscle development,myopathy,and cardiovascular diseases.This review summarizes the role of FHL1 in the tumorigenesis of different kinds of tumors,aiming to provide some ideas on potential biomarkers and therapeutic targets clinically.

关 键 词：4个半LIM结构域蛋白1 肿瘤 治疗靶点 

分 类 号：R730.2[医药卫生—肿瘤]