局灶性缺血性卒中动物模型制作研究进展  

Research progress of focal ischemic stroke in production of animal models

作　　者：席娅琳 王慧瑜 鹿树军[1] XI Yalin;WANG Huiyu;LU Shujun(Department of Neurology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院神经内科,山东滨州256600

出　　处：《中国比较医学杂志》2023年第2期140-148,共9页Chinese Journal of Comparative Medicine

摘　　要：脑血管病是影响人类健康的重大疾病,具有高患病率、高致残率、高死亡率、高复发率和高治疗成本等五大特点,其中缺血性脑卒中疾病约占80%。深入研究该疾病的病理生理反应、治疗反应机制及神经保护药物的开发,动物模型是必不可少的前提。动物缺血性卒中模型可分为全脑性与局灶性缺血性卒中模型两大类,其中对局灶性缺血模型的研究较多且更为深入。鉴于模型的多样性,研究者也可根据研究内容及实际需要自行选择所需的动物脑缺血制作模型。现对局灶性缺血性卒中动物模型制作进展作一综述,并对局灶性缺血性卒中模型动物的选择、各种模型的优缺点以及最常用的线栓法制作大鼠局灶性缺血性卒中模型注意事项进行简要阐述,为后续的脑缺血模型的制作与研究提供参考。Cerebrovascular disease,which has high prevalence;high disability,mortality,and recurrence rates and is associated with high costs,is a major disease affecting human health.Ischemic stroke occurs in approximately 80%of cases.Animal model studies are essential if we want an in-depth understanding of the pathophysiology of the disease,therapeutic response mechanisms,and how to develop neuroprotective drugs.Animal models of ischemic stroke can be divided into global and focal ischemic stroke models,and there have been deeper explorations of focal ischemia models.Given the diversity of models,researchers can also choose an animal model of cerebral ischemia according to the research aims and other needs.The advances made in the production of animal models of focal ischemic stroke,the selection of animal models of focal ischemic stroke,the advantages and disadvantages of various models,and matters needing attention in the making of focal ischemic stroke rat model by intraluminal suture middle cerebral artery occlusion are briefly described.This review provides a reference for the production of and research using subsequent cerebral ischemia models.

关 键 词：局灶性缺血性卒中 实验性卒中模型 线栓法 开颅 光栓 内皮素-1 氯化铁 自发性卒中 

分 类 号：R-33[医药卫生]