以脑膜转移为主要表现的隐匿性结肠癌1例及文献报道  

Occult colon cancer with the main manifestation of leptomeningeal metastasis:A case report and literature review

作　　者：纪怡璠 孟楠[1] 蒋欣[1,3] 谢小华 刘卫刚 田丛娜[4] 董艳红[1,3] 吕佩源[1,2,3] JI Yifan;MENG Nan;JIANG Xin;XIE Xiaohua;LIU Weigang;TIAN Congna;DONG Yanhong;LÜPeiyuan(Department of Neurology,Hebei General Hospital,Shijiazhuang,Hebei 050051,China;Graduate School of Hebei Medical University,Shijiazhuang,Hebei 050017,China;Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders,Shijiazhuang,Hebei 050051,China;Department of Nuclear Medicine,Hebei General Hospital,Shijiazhuang,Hebei 050051,China)

机构地区：[1]河北省人民医院神经内科,河北石家庄050051 [2]河北医科大学研究生学院,河北石家庄050017 [3]河北省脑网络与认知障碍疾病重点实验室,河北石家庄050051 [4]河北省人民医院核医学科,河北石家庄050051

出　　处：《国际神经病学神经外科学杂志》2023年第1期55-58,共4页Journal of International Neurology and Neurosurgery

基　　金：2020河北省高端人才资助项目(83587216);2019河北省政府资助临床医学优秀人才培养项目(冀财社:2019-139-5)。

摘　　要：脑膜癌病(MC)是指恶性肿瘤播散或浸润软脑(脊)膜、蛛网膜下腔,而脑实质不受累的一类疾病,为中枢神经系统转移瘤的少见类型,在实体瘤患者中发生率极低。MC起病隐袭,症状复杂无特异性,患者可呈头痛、意识改变及多种神经功能缺损表现,对于原发灶不明而以脑病为首发症状者,极易误诊、漏诊。现就1例以脑膜转移为首发表现、原发灶为结肠腺癌患者的临床资料进行分析,旨在提高对此病的警惕和认识。Meningeal carcinomatosis(MC)is a disease of malignant tumor dissemination or invasion in the leptomeninges/meninges and the subarachnoid space without the involvement of brain parenchyma,and it is a rare type of metastatic tumor of the central nervous system and has an extremely low incidence rate in patients with solid tumor.MC often has an insidious onset and displays complex but nonspecific symptoms,and patients may have the manifestations of headache,change in consciousness,and various neurological defects,which may lead to misdiagnosis and missed diagnosis in patients with unknown primary lesions and encephalopathy as the initial symptom.This article analyzes the clinical data of a patient with the initial manifestation of leptomeningeal metastasis and the primary lesion of colonic adenocarcinoma,in order to improve the awareness of this disease.

关 键 词：脑膜癌病 继发性肿瘤 多颅神经损害 脑脊液 结肠腺癌 

分 类 号：R739.41[医药卫生—肿瘤]