MALDI-TOF-MS技术应用于消化道肿瘤蛋白组学的研究进展  

Research progress of MALDI-TOF-MS technique applied to proteomics of gastrointestinal tumors

作　　者：徐皓 程彩霞[1] XU Hao;CHENG Caixia(Department of Pathology,the First Clinical College of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院病理科,山西太原030001

出　　处：《胃肠病学和肝病学杂志》2023年第3期321-325,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：基质辅助激光解吸电离飞行时间质谱(matrix-assisted laser desorption ionization time-of-flight mass spectrometry, MALDI-TOF-MS)技术作为一种生物质谱技术,可广泛应用于基因突变检测、基因多态性研究、微生物鉴定、肿瘤生物学标志物检测等方面,其对于早期疾病的发现、治疗以及评估预后有着重要指导意义,已成为精准医学领域不可缺少的分子诊断技术。本文对MALDI-TOF-MS技术在消化道肿瘤蛋白质组学的应用方面进行综述。Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS),as a biological mass spectrometry technology,can be widely used in gene mutation detection,gene polymorphism research,microbial identification,tumor biomarker detection.It has important guiding significance for the discovery,treatment and evaluation of prognosis of early diseases.At present,MALDI-TOF-MS have become an indispensable molecular diagnostic technology in the field of precision medicine.This article reviewed the application of MALDI-TOF-MS in proteomics of gastrointestinal tumors.

关 键 词：基质辅助激光解吸电离飞行时间质谱 蛋白质组学 消化道肿瘤 

分 类 号：R735[医药卫生—肿瘤]