阿加曲班治疗急性前循环脑梗死的疗效观察及对Lp-PLA2、NSE水平的影响  

Observation on efficacy of agatroban on acute anterior circulation cerebral infarction and its influence on the level of Lp-PLA2 and NSE

作　　者：姚广明 YAO Guang-ming(Second Department of Neurology,Shenyang Red Cross Hospital,Shenyang 110000,China)

机构地区：[1]沈阳红十字会医院神经内二科,110000

出　　处：《中国实用医药》2023年第7期100-103,共4页China Practical Medicine

摘　　要：目的分析急性前循环脑梗死患者实施阿加曲班治疗的临床疗效及对脂蛋白磷脂酶A2(Lp-PLA2)、神经元特异性烯醇化酶(NSE)水平的影响。方法100例急性前循环脑梗死患者,随机分为对照组和观察组,每组50例。对照组患者采用阿司匹林治疗,观察组患者在对照组治疗基础上加用阿加曲班治疗。对比两组患者Lp-PLA2、NSE水平,炎症因子,活化部分凝血活酶时间(APTT)、神经功能评分及生活质量评分。结果治疗后,观察组患者Lp-PLA2(101.32±14.68)μg/L、NSE(17.44±4.41)μg/L,低于对照组患者的(108.31±15.41)、(20.16±7.36)μg/L,差异有统计学意义(P<0.05)。治疗后,观察组患者美国国立卫生研究院卒中量表(NIHSS)评分为(5.19±3.17)分,低于对照组患者的(7.15±4.18)分;日常生活能力评定量表(Barthel指数)为(74.16±4.77)分,高于对照组患者的(61.36±4.97)分,差异有统计学意义(P<0.05)。观察组APTT为(42.58±8.11)s,长于对照组的(39.61±7.47)s,差异有统计学意义(P<0.05)。观察组患者白细胞介素-6、肿瘤坏死因子、高敏C反应蛋白水平分别为(106.51±26.36)ng/L、(75.15±12.36)ng/L、(1.67±0.52)mg/L,低于对照组的(141.36±29.13)ng/L、(90.33±17.60)ng/L、(2.03±0.60)mg/L,差异有统计学意义(P<0.05)。结论采用阿加曲班治疗急性前循环脑梗死效果显著,有助于恢复患者脑功能,改善血管内皮炎症反应,提升临床治疗效果及生活水平,达到良好的疾病治疗效果,患者对治疗整体情况满意,具有临床推广价值。Objective To analyze the clinical efficacy of agatroban on acute anterior circulation cerebral infarction and its influence on the level of lipoprotein phospholipase A2(Lp-PLA2)and neuron-specific enolase(NSE).Methods A total of 100 patients with acute anterior circulation cerebral infarction were randomly divided into control group and observation group,with 50 cases in each group.Patients in the control group was treated with aspirin,and patients in the observation group were treated with agatroban on the basis of the control group.The levels of Lp-PLA2,NSE,and inflammatory factors,activated partial thromboplastin time(APTT),neurological function score and quality of life score were compared between the two groups.Results After treatment,the observation group had Lp-PLA2 of(101.32±14.68)μg/L and NSE of(17.44±4.41)μg/L,which were lower than those of(108.31±15.41)and(20.16±7.36)μg/L in the control group,and the differences were statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score of the observation group was(5.19±3.17)points,which was lower than that of(7.15±4.18)points of the control group;the Barthel Index score of the observation group was(74.16±4.77)points,which was higher than that of(61.36±4.97)points of the control group;the differences were statistically significant(P<0.05).The APTT of(42.58±8.11)s in the observation group was longer than that of(39.61±7.47)s in the control group,and the difference was statistically significant(P<0.05).The levels of interleukin-6,tumor necrosis factor and highsensitivity C-reactive protein in the observation group were(106.51±26.36)ng/L,(75.15±12.36)ng/L and(1.67±0.52)mg/L,which were lower than those of(141.36±29.13)ng/L,(90.33±17.60)ng/L and(2.03±0.60)mg/L in the control group,and the differences were statistically significant(P<0.05).Conclusion Agatroban has significant effects in the treatment of acute anterior circulation cerebral infarction,which can help to restore the brain function of patie

关 键 词：急性前循环脑梗死 阿加曲班 脂蛋白磷脂酶A2 神经元特异性烯醇化酶 神经功能 生活质量 

分 类 号：R743.33[医药卫生—神经病学与精神病学]