RIG-Ⅰ、USP5在卵巢上皮性癌组织中的表达水平及预后意义  

The expression level of RIG-I and USP5 in epithelial ovarian cancer and its clinical prognostic significance

作　　者：齐曼[1] 芦秋彤 刘少卿[1] 张娟 崔艳萍 刘咏梅[4] QI Man;LU Qiutong;LIU Shaoqing;ZHANG Juan;CUI Yanping;LIU Yongmei(Chemotherapy Centre,Chengde Central Hospital,Chengde 067000,Hebei,China;Department of Pharmacy Clinical Pharmacy Room,Chengde Central Hospital,Chengde 067000,Hebei,China;Department of Internal Medicine,Xinle Hospital,Shijiazhuang 050700,Hebei,China;Department of Obstetrics and Gynecology,Chengde Central Hospital,Chengde 067000,Hebei,China)

机构地区：[1]承德市中心医院放化疗中心,河北承德067000 [2]承德市中心医院药剂科临床药学室,河北承德067000 [3]新乐市医院内科,河北石家庄050700 [4]承德市中心医院妇产科,河北承德067000

出　　处：《中南医学科学杂志》2023年第2期277-280,共4页Medical Science Journal of Central South China

基　　金：承德市科技支撑项目(201904A013)。

摘　　要：目的 探讨维甲酸诱导基因-Ⅰ(RIG-Ⅰ)、泛素特异性肽酶5(USP5)在卵巢上皮性癌组织中的表达水平及预后意义。方法 选取98例卵巢上皮性癌组织样本为病例组,同期98例正常卵巢组织为对照组。免疫组化法测定两组RIG-Ⅰ、USP5表达水平。单因素及多因素Cox回归分析RIG-Ⅰ、USP5表达水平与卵巢上皮性癌患者临床预后的关系。结果 病例组RIG-Ⅰ、USP5表达阳性率均高于对照组(P<0.05)。卵巢上皮性癌患者RIG-Ⅰ、USP5表达与肿瘤最大径、TNM分期、肿瘤浸润、分化程度、淋巴结转移、复发率相关(P<0.05)。RIG-Ⅰ、USP5阳性的卵巢上皮性癌患者5年生存率均分别低于RIG-Ⅰ、USP5阴性的卵巢上皮性癌患者(P<0.05)。单因素分析显示:肿瘤最大径≥2 cm、TNM分期Ⅲ~Ⅳ期、浸润深度≥1 cm、分化程度高、淋巴结转移、复发、RIG-Ⅰ阳性、USP5阳性的卵巢上皮性癌患者5年生存率分别低于肿瘤最大径<2 cm、TNM分期Ⅰ~Ⅱ期、浸润深度<1 cm/无浸润、分化程度低、无淋巴结转移、无复发、RIG-Ⅰ阴性、USP5阴性的卵巢上皮性癌患者(P<0.05)。多因素Cox回归分析显示:TNM分期Ⅲ~Ⅳ期、分化程度高、RIG-Ⅰ和USP5表达阳性均是影响卵巢上皮性癌患者预后的独立危险因素(P<0.05)。结论 RIG-Ⅰ、USP5与卵巢上皮性癌患者临床病理特征相关;RIG-Ⅰ、USP5阳性表达是卵巢上皮性癌预后危险因素。Aim To investigate the expression level and prognostic significance of retinoic acid inducible gene-I(RIG-I)and ubiquitin specific proteas5(USP5)in epithelial ovarian cancer.Methods 98 epithelial ovarian cancer tissue samples were selected as the case group,and 98 normal ovarian tissues during the same period were selected as the control group.The expression levels of RIG-I and USP5 in the two groups of samples were determined by immunohistochemistry.The relationship between the expression levels of RIG-I and USP5 and the clinical prognosis of patients with epithelial ovarian cancer were explored by univariate and multivariate Cox regression.Results The positive rates of RIG-I and USP5 protein expression in the case group were higher than those in control group(P<0.05).The positive expression rates of RIG-I and USP5 in patients with epithelial ovarian cancer were related to the maximum tumor diameter,TNM stage,tumor invasion,differentiation grade,lymph node metastasis and recurrence(P<0.05).The 5-year survival rates of patients with positive RIG-I or USP5 were lower than those of patients with negative RIG-I or USP5(P<0.05).Univariate analysis showed that the 5-year survival rate of patients with the largest tumor diameter≥2 cm,TNM stageⅢ-Ⅳ,depth of invasion≥1 cm,high differentiation grade,lymph node metastasis,recurrence,RIG-I positive,USP5 positive were lower than those of the patients with tumor maximum diameter<2 cm,TNM stageⅠ-Ⅱ,depth of invasion<1 cm/no invasion,low differentiation grade,no lymph node metastasis,no recurrence,RIG-I negative,USP5 negative(P<0.05).Multivariate Cox regression analysis showed that TNM stageⅢ-Ⅳ,high differentiation grade,positive expression of RIG-I and USP5 were independent risk factors for the prognosis of patients with epithelial ovarian cancer(P<0.05).Conclusions RIG-I and USP5 are related to the clinicopathological characteristics of patients with epithelial ovarian cancer.The positive expression of RIG-I and USP5 are prognostic risk factors for epithelial ov

关 键 词：维甲酸诱导基因Ⅰ 泛素特异性肽酶5 卵巢上皮性癌 

分 类 号：R737.31[医药卫生—肿瘤]