G-CIMP表达在胶质瘤中的研究进展  

Research progress of G-CIMP expression in glioma

作　　者：齐泽迪 陈胜利[1] 屈一晨 张明达 胡昌晨 QI Zedi;CHEN Shengli;QU Yichen;ZHANG Mingda;HU Changchen(Department of Neurosurgery,the Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030000,Shanxi,China)

机构地区：[1]山西医科大学第五临床医学院神经外科,山西太原030000

出　　处：《中南医学科学杂志》2023年第2期299-301,共3页Medical Science Journal of Central South China

基　　金：国家自然科学基金(30901774);山西省人民医院省级专项配套经费科研项目(sj20019003)。

摘　　要：胶质瘤起源于神经胶质细胞,以发病率高和预后差为特点。胶质瘤CPG岛甲基化表型(G-CIMP)作为DNA甲基化的一种,是近年新发现的一种表观遗传学改变,与胶质瘤的分子特征及临床特点均有关。本文就G-CIMP的发现、分子学特征、临床意义及展望展开综述。Glioma arise from glial cells and are characterized by a high incidence rate and poor prognosis.As a type of DNA methylation,glioma CPG island methylation phenotype(G-CIMP),is an epigenetic change newly discovered in recent years and is related to both the molecular characteristics and clinical features of glioma.This paper reviews the discovery,molecular characteristics,clinical significance and prospect of G-CIMP.

关 键 词：CPG岛甲基化表型 DNA甲基化 胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]