PET/CT对NSCLC异质性显像表征的研究进展  

Progress of PET/CT for heterogeneous imaging characterization of NSCLC

作　　者：宾莉 翁娜 黄丹琪 李国栋 王旭[1] BIN Li;WENG Na;HUANG Danqi;LI Guodong;WANG Xu(Department of Nuclear Medicine,Binzhou Medical University Hospital,Shandong Binzhou 256603,China;School of Medical Imaging,Binzhou Medical University,Shandong Yantai 264100,China.)

机构地区：[1]滨州医学院附属医院核医学科,山东滨州256603 [2]滨州医学院医学影像学院,山东烟台264100

出　　处：《现代肿瘤医学》2023年第7期1332-1335,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81771828);山东省自然科学基金(编号:ZR2017MH037);山东省高校计划(编号:J18KB116)。

摘　　要：肺癌发病率及死亡率居我国恶性肿瘤首位,非小细胞肺癌(non-small cell lung cancer,NSCLC)占肺癌的绝大多数,肿瘤内异质性(intratumor heterogeneity,ITH)较其他肿瘤更高,了解ITH有利于推进NSCLC的个体化精准医疗。相较于组织病理活检,PET/CT的成熟应用为ITH的全面无创表征提供可能。本文主要就PET/CT对NSCLC中的特定基因表达、肿瘤内部免疫微环境、癌细胞空间排布、肿瘤细胞的增殖程度以及转移潜能的研究进展进行系统综述,以期为NSCLC的临床诊断及治疗提供依据。Lung cancer incidence and mortality rates rank first among malignant tumors in China.Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancers and has higher intratumor heterogeneity(ITH)than other tumors,and understanding ITH is beneficial to advancing individualized precision medicine for NSCLC.Compared with histopathological biopsy,the mature application of PET/CT offers the possibility of comprehensive non -invasive characterization of ITH.This article focuses on a systematic review of the research progress of PET/CT on specific gene expression,immune microenvironment within the tumor,spatial arrangement of cancer cells,the degree of tumor proliferation,and the potential of a metastatic phenotype in NSCLC,to provide a reference for clinical diagnosis and treatment of NSCLC.

关 键 词：PET/CT 非小细胞肺癌 肿瘤内异质性 代谢显像 

分 类 号：R734.2[医药卫生—肿瘤]