胃癌组织中EGFR、FN1表达水平及其临床意义  

Expression Levels and Clinical Significance of EGFR and FN1 in Gastric Cancer Tissues

作　　者：闫小燕 李鹏飞 李真真 申娜娜 张红鸽[1] 孟敏[1] YAN Xiaoyan;LI Pengfei;LI Zhenzhen(Anyang People's Hospital,Anyang,455000)

机构地区：[1]河南省安阳市人民医院,455000

出　　处：《实用癌症杂志》2023年第4期545-549,共5页The Practical Journal of Cancer

摘　　要：目的 探讨胃癌组织中表皮生长因子受体(EGFR)、纤维连接蛋白(FN1)表达水平及其临床意义。方法选取胃癌患者手术切除胃癌组织标本107例及对应癌旁组织60例,检测EGFR蛋白、FN1蛋白表达水平,分析其与患者临床病理特征及随访3年预后的关系。结果 胃癌癌组织EGFR蛋白、FN1蛋白高表达率分别为44.86%、50.47%,均高于癌旁组织(11.67%、8.33%)(P<0.05);不同性别、年龄以及肿瘤部位、肿瘤大小癌组织中EGFR、FN1蛋白表达水平比较(P>0.05);低分化、Ⅲ~Ⅳ期、侵及浆膜、淋巴结转移者胃癌组织EGFR、FN1蛋白表达水平高于中高分化、Ⅰ~Ⅱ期、未侵及浆膜、无淋巴结转移者(P<0.05);Logisitic回归分析显示:临床分期高、分化低、侵及浆膜、淋巴结转移是胃癌组织EGFR、FN1蛋白高表达的影响因素;随访3年,Kaplain-Maier生存分析显示EGFR蛋白、FN1蛋白高表达者3年总生存率[41.6%(20/48)、44.44%(24/54)]低于低表达者[64.41%(38/59)、60.38%(32/53)](P<0.05);EGFR蛋白、FN1蛋白高表达者3年无进展生存率[27.08%(13/48)、29.63%(16/54)]低于低表达者[49.15%(29/59)、49.06%(26/53)](P<0.05)。结论 胃癌组织中EGFR、FN1呈现高表达,且其高表达水平与肿瘤分期、分化、浸润及淋巴结转移有关,预后不良。Objective To explore the expression levels and clinical significance of epidermal growth factor receptor(EGFR) and fibronectin-1(FN1) in gastric cancer tissues.Methods The specimens of gastric cancer tissues from 107 patients with gastric cancer and corresponding para-cancerous tissues from 60 patients were collected.The expression levels of EGFR and FN1 proteins were detected.And their correlation with clinicopathological characteristics and prognosis was analyzed.Results The high-expression rates of EGFR and FN1 proteins in gastric cancer tissues were 44.86% and 50.47%,higher than those in para-cancerous tissues(11.67%,8.33%)(P0.05).The difference in expression levels of EGFR and FN1 proteins in cancer tissues among patients with different genders,age,tumor sites and size was not statistically significant(P0.05).The expression levels of EGFR and FN1 proteins in gastric cancer tissues in patients with low differentiation,stages Ⅲ~Ⅳ,tumor infiltrating serosa and lymph node metastasis were higher than those with moderate-high differentiation,stages Ⅰ~Ⅱ,tumor not infiltrating serosa and lymph node non-metastasis(P>0.05).Logisitic regression analysis showed that high clinical staging,low differentiation,tumor infiltration serosa and lymph node metastasis were influencing factors of high-expression EGFR and FN1 proteins in gastric cancer tissues.After 3 years of follow-up,the results of Kaplain-Maier survival curve analysis showed that 3-year overall survival rates in patients with high-expression EGFR protein and FN1 protein were 41.6%(20/48) and 44.44%(24/54),lower than those with low expressions [64.41%(38/59),60.38%(32/53)](P<0.05).The 3-year progression-free survival rates in patients with high-expression EGFR protein and FN1 protein were 27.08%(13/48) and 29.63%(16/54),lower than those with low expressions [49.15%(29/59),49.06%(26/53)](P<0.05).Conclusion The expressions of EGFR and FN1 are up-regulated in gastric cancer tissues,which are related to tumor staging,differentiation,tumor infiltration and ly

关 键 词：胃癌 临床病理 预后 表皮生长因子受体 纤维连接蛋白 

分 类 号：R735.2[医药卫生—肿瘤]