乳腺癌组织中PAX8、MECOM表达及与其临床病理特征、淋巴结转移的关系  

Expression of PAX8 and MECOM in Breast Cancer Tissues and Their Relationship with Clinicopathologic Features and Lymph Node Metastasis

作　　者：董欢欢[1] 陈萍[1] 宋黄瑜 郭攀攀[1] 赵婕[1] 杨晓静[1] 刘宁[1] 郭静[1] 杜闯 DONG Huanhuan;CHEN Ping;SONG Huangyu(The 7th People's Hospital of Zhengzhou,Zhengzhou,450000)

机构地区：[1]河南省郑州市第七人民医院,450000

出　　处：《实用癌症杂志》2023年第4期554-557,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190146)。

摘　　要：目的 探讨乳腺癌组织中配对盒基因8抗体(PAX8)、MECOM表达水平及与其临床病理特征、淋巴结转移的关系。方法 选取乳腺癌患者76例,均经乳腺癌根治手术治疗,切除癌组织和癌旁组织(距病灶>5 cm),收集乳腺癌患者临床基本资料。采用免疫组化检测PAX8、MECOM表达。比较乳腺癌患者癌组织和癌旁组织中PAX8、MECOM阳性表达率,比较PAX8、MECOM不同表达与患者临床基本资料及淋巴结转移的关系。结果 癌组织中PAX8总阳性率(61.8%)高于癌旁组织(36.8%)(χ^(2)=9.502,P=0.002);癌组织MECOM总阳性率(68.4%)高于癌旁组织(32.9%)(χ^(2)=19.188,P<0.001)。PAX8表达阳性乳腺癌患者脉管内栓塞发生率及雌、孕激素受体阳性率高于PAX8表达阴性患者(P<0.05);MECOM表达阳性乳腺癌患者组织学分级程度、脉管内栓塞发生率及雌、孕激素受体阳性率高于MECOM表达阴性患者(P<0.05)。PAX8、MECOM表达阳性乳腺癌患者淋巴结转移例数和淋巴结转移TNM分期程度均高于PAX8、MECOM表达阴性患者(P<0.05)。结论 PAX8、MECOM阳性表达与乳腺癌患者脉管内栓塞、雌、孕激素受体有关,此外MECOM阳性率还与乳腺癌组织学分级程度有关,与乳腺癌淋巴结转移及分期关系密切。Objective To investigate the expression of paired-box gene 8 antibody(PAX8)and MDS1 and EVI1 complex locus(MECOM)in breast cancer tissues and their relationship with clinicopathologic features and lymph node metastasis.Methods 76 patients underwent radical surgical treatment of breast cancer were enrolled,and the pairs of cancer tissues and adjacent normal tissues(>5cm from the lesion)were resected.The basic clinical data of patients were collected.The expression of PAX8 and MECOM was detected by immunohistochemistry.The positive expression rates of PAX8 and MECOM were compared between cancer tissues and adjacent normal tissues.Then the relationship between the expressions of PAX8 and MECOM and the basic clinical information and lymph node metastasis of patients was discussed.Results The overall PAX8 positive rate was 61.8%in cancer tissues,which was higher than 36.8%in adjacent normal tissues(χ^(2)=9.502,P=0.002).The overall MECOM positive rate was 68.4%in cancer tissues,which was higher than 32.9%in adjacent normal tissues(χ^(2)=19.188,P<0.001).The incidence rate of intravascular thrombosis,estrogen and progesterone receptor positive in breast cancer patients with positive PAX8 expression were higher than those in patients with negative PAX8 expression(P<0.05).The histological grade,incidence of intravascular thrombosis,estrogen and progesterone receptor positive in breast cancer patients with positive MECOM expression were higher than those in patients with negative MECOM expression(P<0.05).The number and TNM staging of lymph node metastasis in breast cancer patients with positive PAX8 and MECOM expression were higher than those in breast cancer patients with negative PAX8 and MECOM expression,respectively(P<0.05).Conclusions The positive expression of PAX8 and MECOM is related to intravascular thrombosis,estrogen and progesterone receptors in patients with breast cancer.In addition,MECOM positivity is associated with the degree of histological grading of breast cancer and is closely related to lymph node me

关 键 词：乳腺癌 配对盒基因8抗体 MECOM 淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]